◀ Back to BCL2

BAD — BCL2

Pathways - manually collected, often from reviews:

• BioCarta regulation of bad phosphorylation: BAD → BAD/BCL-2 complex (BAD-BCL2) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: BAD → BCL-2 (BCL2) (modification, collaborate)
• BioCarta regulation of bad phosphorylation: BAD/BCL-2 complex (BAD-BCL2) → BCL-2 (BCL2) (modification, collaborate)
• BioCarta regulation of bad phosphorylation: BAD → BAD/BCL-2 complex (BAD-BCL2) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: BAD → BCL-2 (BCL2) (modification, collaborate)
• BioCarta regulation of bad phosphorylation: BAD/BCL-2 complex (BAD-BCL2) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: BAD/BCL-2 complex (BAD-BCL2) → BCL-2 (BCL2) (modification, collaborate)
• BioCarta regulation of bad phosphorylation: BAD/BCL-2 complex (BAD-BCL2) → AKT (AKT1) (modification, collaborate)
• KEGG Tuberculosis: BAD → BCL2 (protein-protein, dissociation)
• Reactome Reaction: BAD → BCL2 (reaction)
• Reactome Reaction: BAD → BCL2 (direct_complex)
• WikiPathways DNA Damage Response (only ATM dependent): BAD → BCL2 (inhibition) Strasser et al., Nat Rev Immunol 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: BAD — BCL2 (two hybrid) Inohara et al., EMBO J 1997*
• IRef Bind_translation Interaction: BAD — BCL2 (coimmunoprecipitation) Chen et al., Mol Cell 2005
• IRef Bind_translation Interaction: BAD — BCL2 (competition binding) Chen et al., Mol Cell 2005
• IRef Bind_translation Interaction: BAD — BCL2 (coimmunoprecipitation) Edlich et al., EMBO J 2005
• IRef Bind_translation Interaction: BAD — BCL2 (affinity chromatography technology) Edlich et al., EMBO J 2005
• IRef Bind_translation Interaction: BAD — BCL2 (two hybrid) Cartron et al., Mol Cell 2004*
• IRef Biogrid Interaction: BAD — BCL2 (physical association, affinity chromatography technology) Yang et al., Cell 1995*
• IRef Biogrid Interaction: BAD — BCL2 (direct interaction, two hybrid) Yang et al., Cell 1995*
• IRef Biogrid Interaction: BAD — BCL2 (physical association, affinity chromatography technology) Edlich et al., EMBO J 2005
• IRef Biogrid Interaction: BAD — BCL2 (direct interaction, pull down) Jin et al., J Biol Chem 2005*
• IRef Biogrid Interaction: BAD — BCL2 (physical association, affinity chromatography technology) Chen et al., Mol Cell 2005
• IRef Innatedb Interaction: BAD — BCL2 (unknown, -) Jin et al., J Biol Chem 2005*
• IRef Intact Interaction: BAD — BCL2 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Intact Interaction: BAD — BCL2 (direct interaction, surface plasmon resonance) Chen et al., Mol Cell 2005
• IRef Intact Interaction: BAD — BCL2 (physical association, anti bait coimmunoprecipitation) Maiuri et al., EMBO J 2007*
• IRef Intact Interaction: BAD — BCL2 (physical association, two hybrid) Ottilie et al., J Biol Chem 1997*
• IRef Intact Interaction: BAD — BCL2 (physical association, enzyme linked immunosorbent assay) Ottilie et al., J Biol Chem 1997*
• IRef Intact Interaction: BAD — BCL2 (physical association, anti bait coimmunoprecipitation) Huang et al., EMBO J 1998*
• IRef Ophid Interaction: BAD — BCL2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Pastorino et al., J Biol Chem 1999 : Phosphorylation of BAD prevents its interaction with the antiapoptotic protein Bcl-XL
Condorelli et al., Mol Cell Biol 2001 : The generation of truncated BAD was blocked by Bcl-2 in IL-3 deprived 32Dcl3 cells but not in Jurkat T cells exposed to anti-FAS antibody, TNF-alpha, or TRAIL
Singh et al., Molecular cancer 2009 (Neoplasm Invasiveness...) : IL-8 depletion caused significant decreases in anti-apoptotic proteins, BCL-2, BCL-xL due to decrease in both mRNA and post-translational stability, and increased levels of pro-apoptotic BAX and BAD proteins
Malla et al., J Neurooncol 2012 (Glioma) : In the present study, efficient downregulation of uPAR and cathepsin B increased the translocation of calcineurin A from the mitochondria to the cytosol, decreased pBAD ( S136 ) expression and its interaction with 14-3-3? and increased the interaction of BAD with Bcl-xl