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HDAC2 — INS
Text-mined interactions from Literome
Larsen et al., Diabetologia 2007
:
HDAC inhibition
reduced cytokine mediated decrease in
insulin secretion and increase in iNOS levels, NO formation and apoptosis
Sangha et al., Curr Opin Oncol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Two treatment strategies, in development, seem particularly appealing for further study
: insulin-like growth factor receptor ( IGF-1R ) and
histone deacetylase (HDAC) inhibition
Lundh et al., Diabetologia 2012
(Diabetes Mellitus, Type 1) :
Small hairpin RNAs against HDAC1 and -3, but not
HDAC2 ,
reduced pro-inflammatory cytokine induced beta cell apoptosis in
INS-1 and primary rat islets