Gene interactions and pathways from curated databases and text-mining

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HDAC2 — INS

Text-mined interactions from Literome

Larsen et al., Diabetologia 2007 : HDAC inhibition reduced cytokine mediated decrease in insulin secretion and increase in iNOS levels, NO formation and apoptosis
Sangha et al., Curr Opin Oncol 2009 (Carcinoma, Non-Small-Cell Lung...) : Two treatment strategies, in development, seem particularly appealing for further study : insulin-like growth factor receptor ( IGF-1R ) and histone deacetylase (HDAC) inhibition
Lundh et al., Diabetologia 2012 (Diabetes Mellitus, Type 1) : Small hairpin RNAs against HDAC1 and -3, but not HDAC2 , reduced pro-inflammatory cytokine induced beta cell apoptosis in INS-1 and primary rat islets