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INS — PASK

Text-mined interactions from Literome

Borter et al., Diabetes 2007 : A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression
Hao et al., IUBMB Life 2008 (Metabolic Diseases) : In cultured pancreatic beta-cells, PASK is activated by elevated glucose concentrations and is required for glucose stimulated transcription of the insulin gene
Fontés et al., Diabetes 2009 (MAP Kinase Signaling System) : This study aimed to ascertain the role of extracellular regulated kinases ( ERKs ) 1/2, protein kinase B (PKB), and Per-Arnt-Sim kinase (PASK) in palmitate inhibition of insulin gene expression in pancreatic beta-cells ... Overexpression of wild-type PASK increased insulin and pancreatic duodenal homeobox-1 gene expression in MIN6 cells and rat islets incubated with glucose and palmitate, whereas overexpression of a kinase-dead PASK mutant in rat islets decreased expression of insulin and pancreatic duodenal homeobox-1 and increased C/EBPbeta expression