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INS — SLCO6A1

Text-mined interactions from Literome

Nur-E-Kamal et al., Int J Oncol 2000 : GST pi was found to be induced by all the Ras GTPase activating agents tested while activation of Ras by phorbolester and insulin induced expression of GST mu only
Kim et al., J Pharmacol Exp Ther 2003 : Insulin and glucagon effects on GST expression and the signaling pathway involved in the glucagon regulation of GST expression were examined in primary cultured rat hepatocytes ... This study demonstrates that insulin and glucagon regulate, in an opposing manner, the expression of alpha-class GSTs and that glucagon completely inhibits pi-class GST expression in vitro, suggesting that hepatic GST expression may be decreased during diabetes
Yoneda et al., Diabetes Care 1992 (Diabetes Mellitus, Type 2...) : Insulin secretory responses to an OGTT, IVGTT, and GST were studied
Tsai et al., J Nutr 2005 : The induction of GST Yp by L-methionine and L-cysteine restriction was not affected by insulin and dexamethasone, but the latter suppressed GST Yp expression ( P < 0.05 )
Kim et al., J Pharmacol Exp Ther 2006 : The present study examines the signaling pathways involved in the regulation of alpha-class GST in response to insulin in primary cultured rat hepatocytes ... Treatment of cells with the phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002 [ 2- ( 4-morpholinyl ) -8-phenyl-4H-1-benzopyran-4-one ] or rapamycin, an inhibitor of mammalian target of rapamycin and ribosomal p70 S6 kinase (p70S6K) phosphorylation, or with an adenovirus containing green fluorescent protein and a dominant negative and kinase-dead Akt, effectively inhibited the insulin mediated increase in alpha-class GST expression and GST activity toward NBD ... In contrast, PD98059 ( 2'-amino-3'-methoxyflavone ), an inhibitor of mitogen activated protein kinase kinase, SP600125 ( 1,9-pyrazoloanthrone ), an inhibitor of c-Jun N-terminal kinase, SB203580 [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imadazole ], an inhibitor of p38 mitogen activated protein kinase, or bisindolylmaleimide, a broad spectrum inhibitor of protein kinase C, did not inhibit the insulin mediated increase in alpha-class GST protein levels in hepatocytes
Hatayama et al., Jpn J Cancer Res 1991 : These results suggest that the enhanced expression of GST-P induced by EGF or insulin in primary cultured rat hepatocytes might be regulated by JUN and FOS proteins
Carrillo et al., Toxicol Lett 1995 : The insulin dependent increase in cytosolic GST activity was abolished by the pretreatment of the animals with an inhibitor of protein synthesis ( cycloheximide ) ... We propose that : ( 1 ) the effect of insulin on hepatic cytosolic GST activity requires protein synthesis ; ( 2 ) glucagon produces an inhibition of hepatic cytosolic GST, which could be mediated by cytosolic effectors such as adenosine 3'-5'-cyclic monophosphate ( cAMP ) ; ( 3 ) the effects of glucagon and insulin were not mutually exclusive ; ( 4 ) hepatic microsomal GST is regulated by different mechanism ( s )