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INS — SSTR1

Text-mined interactions from Literome

Slagter et al., Regul Pept 2005 : In this study, we used rainbow trout to evaluate the effects of growth hormone (GH), insulin (INS), and insulin-like growth factor-I (IGF-I) on the expression of SSTR 1A , 1B and 2 mRNAs ... INS also regulated SSTR expression in a subtype- and tissue-specific manner ... INS reduced SSTR 1B expression in optic tectum, increased SSTR 2 expression in pancreas, and increased SSTR 1B and 2 expression in liver
Wang et al., J Surg Res 2005 (Body Weight...) : These results suggest that both SSTR5 and SSTR1 play a pivotal role in insulin secretion and glucose regulation in mice and that their regulatory effects are age related
Wang et al., Mol Cell Endocrinol 2006 (Insulin Resistance) : In this study, we used the SSTR1 knockout mouse model to examine the role of SSTR1 in insulin secretion and glucose homeostasis in mice ... These results demonstrate that SSTR1 plays an important role in the regulation of insulin secretion in the endocrine pancreas in mice
Nelson et al., Am J Physiol Regul Integr Comp Physiol 2006 : These findings indicate that INS and GH stimulate SSTR expression by regulating transcription of SSTR mRNAs and by increasing functional SSTRs on the cell surface, and they suggest that regulation of SSTRs may be important for the coordination of growth, development, and metabolism of vertebrates
Singh et al., J Clin Endocrinol Metab 2007 : SSTR1- , SSTR2-, and SSTR5-selective agonists inhibited insulin secretion with the following order of potency : SSTR2 ( EC50, 0.08 nm ) > SSTR5 ( EC50, 5.3 nm ) > SSTR1 ( EC50, 35 nm ) ... SSTR1-, SSTR2- , and SSTR5-selective agonists inhibited insulin secretion with the following order of potency : SSTR2 ( EC50, 0.08 nm ) > SSTR5 ( EC50, 5.3 nm ) > SSTR1 ( EC50, 35 nm )
Fagan et al., Surgery 1998 : This study was undertaken to determine which SSTR ( 2 or 5 ) is responsible for the inhibitory effect of somatostatin on glucose stimulated mouse insulin secretion