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ABL1 — BACH2

Text-mined interactions from Literome

Vieira et al., Genes Chromosomes Cancer 2001 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : In CML myeloid cell lines ( n = 8 ) and BCR/ABL negative lines ( n = 6 ), BACH2 was either undetectable by Northern blotting or did not change in response to STI571, suggesting that BACH2 repression by BCR/ABL may be specifically relevant to lymphoid transformation
Kamio et al., Blood 2003 : The inhibition of BCR/ABL tyrosine kinase activity by STI571 in chronic myeloid leukemia ( CML ) cell lines and CD34+ cells from patients with CML in lymphoid crisis results in induction of BACH2 expression
Casolari et al., Leukemia 2013 (Blast Crisis...) : Transient BCR-ABL expression led to significant reduction in BACH2 promoter activity and this effect was dependent on the kinase function of the oncoprotein ... Overall, our data show that Pax5 functions as an intermediate effector in the Bcr-Abl mediated transcriptional repression of BACH2