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EGF — TERF1
Text-mined interactions from Literome
Lu et al., Exp Cell Res 2000
:
We demonstrate that NGF and
EGF induce
Rap1 activation in PC12-Shb cells, while FGF-2 fails to do so
Wu et al., J Neurosci 2001
(MAP Kinase Signaling System) :
Although both
epidermal growth factor (EGF) and NGF caused transient activation of Ras, only NGF
induced the activation of
Rap1
Ohba et al., EMBO J 2003
:
Epidermal growth factor (EGF) activates Ras and
Rap1 at distinct intracellular regions
Jenei et al., Exp Cell Res 2005
:
E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of
Rap1 in
response to
epidermal growth factor ... Remarkably, we found that
EGF induced
activation of the p21Ras related GTPase
Rap1 was also sensitized in NIH3T3/EGFR-e3B1 cells ... Thus, in NIH3T3/EGFR-e3B1 cells, maximal
EGF induced activation of
Rap1 occurs with a dose of EGF much lower than in NIH3T3/EGFR cells ... We also report that overexpression of e3B1 in NIH3T3/EGFR cells renders
EGF induced activation of
Rap1 completely dependent on Src tyrosine kinases but not on c-Abl ... Accordingly, we propose that overexpression of e3B1 in NIH3T3/EGFR cells leads to mobilization of Src tyrosine kinases that participate in
EGF induced activation of
Rap1 and inhibition of cell proliferation
Okada et al., J Biol Chem 1997
:
Insulin and
epidermal growth factor stimulate a conformational change in
Rap1 and dissociation of the CrkII-C3G complex