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FOXO3 — PI3

Text-mined interactions from Literome

Zheng et al., J Biol Chem 2000 : The phosphorylation of Akt and FKHRL1 induced by 10 nm IGF-1 was inhibited by the phosphatidylinositide 3-kinase (PI3K) inhibitors wortmannin ( 0.25-2 microm ) and LY294002 ( 12.5-100 microm ), but not by the MEK inhibitor PD98059 ( 50 microm ) or the p70 S6 kinase pathway inhibitor rapamycin ( 50 nm ), suggesting that the phosphorylation of FKHRL1 induced by IGF-1 is mediated by the PI3K pathway
Weinkove et al., BMC biology 2006 : Long-term starvation and ageing induce AGE-1/PI 3-kinase dependent translocation of DAF-16/FOXO to the cytoplasm
Terragni et al., BMC cell biology 2008 : Computational analyses followed by chromatin immunoprecipitations demonstrated FOXO binding to both previously known and novel sites in promoter regions of approximately one-third of the up-regulated genes, consistent with activation of FOXO1 and FOXO3a in response to inhibition of PI 3-kinase
Terragni et al., J Biol Chem 2011 : Inhibition of PI 3-kinase led to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1, as well as FoxO
Ganesan et al., Thorax 2013 (Disease Models, Animal...) : In COPD airways, aberrant EGFR activity increases PI 3-kinase/Akt mediated phosphorylation of FoxO3A , thereby decreasing nuclear FoxO3A and increasing chemokine expression