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IL6 — PTPRC
Text-mined interactions from Literome
Ishikawa et al., Leukemia & lymphoma 2000
(Multiple Myeloma) :
IL-6 can also
induce expression of
CD45 on the MPC-1- CD45- subpopulation of immature myeloma cells ... In the U266 cell line,
IL-6 leads to the induction of
CD45 expression and cell proliferation, indicating that IL-6 induced effects are closely linked to CD45 expression
Gao et al., Exp Hematol 2000
:
FcgammaRIIa cross linking resulted in significantly increased concentrations of secreted IL-6 compared to untreated neutrophils, and
IL-6 production was further
enhanced by cocross linking
CD45 with FcgammaRIIa ... Cross linking
CD45 alone also
induced IL-6 production
Kawano et al., Int J Hematol 2002
(MAP Kinase Signaling System...) :
In the U-266 cell lines,
IL-6 can
lead to the induction of
CD45 expression and CD45+ U-266 cells can proliferate in response to IL-6
Zhou et al., Int J Hematol 2004
(Multiple Myeloma) :
The protein tyrosine phosphatase
CD45 is
required for
interleukin 6 signaling in U266 myeloma cells ... An association between
CD45 and the Src-family protein tyrosine kinase, Lyn, was maintained in the
presence of
IL-6 ; the formation of the CD45/Lyn complex was impaired by vanadate
Li et al., Blood 2005
(Multiple Myeloma) :
Here, we showed that
IL-6 induced the translocation of
CD45 to lipid rafts in an isoform dependent manner
Piercy et al., Immunology 2006
:
CD45 negatively
regulates tumour necrosis factor and
interleukin-6 production in dendritic cells
Collette et al., Eur Cytokine Netw 2007
(Multiple Myeloma) :
Using a pharmacological Erk inhibitor, we show that the Erk/MAPK pathway is involved in
IL-6 induced clonogenicity of CD45+, but not
CD45- myeloma cell lines
Corvaïa et al., Eur J Immunol 1995
:
In contrast to calcium mobilization and tyrosine phosphorylation of proteins,
IL-6 production was not
affected by co-cross linking of
CD45 with either Fc gamma RI or Fc gamma RII ... Interestingly, cross linking of the
CD45 itself was
sufficient to induce
IL-6 production
Mahmoud et al., Blood 1998
(Multiple Myeloma) :
Induction of
CD45 expression and proliferation in U-266 myeloma cell line by
interleukin-6 ... Moreover, we showed that
IL-6 stimulation
led to the induction of expression of
CD45 and cellular proliferation ... Our data show that the expression pattern of CD45 in myeloma cell lines is heterogeneous and show for the first time that
CD45 expression can be
induced by
IL-6 stimulation