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CRK — RHOA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Tsuda et al., J Biol Chem 2004
:
Herein, we report that
Crk associates with ERM family proteins ( including ezrin, radixin, and moesin ),
activates RhoA , and promotes cell motility toward hyaluronic acid ... In concert with the
activation of
RhoA by
Crk , Crk was found to associate with Rho-GDI, which has been shown to bind to ERMs
Zeidan et al., Cardiovasc Res 2008
(Cardiomegaly) :
Leptin induced cardiomyocyte hypertrophy involves selective caveolae and
RhoA/ROCK dependent
p38 MAPK translocation to nuclei
Shafikhani et al., Cell cycle (Georgetown, Tex.) 2008
:
Our data demonstrate that the subcellular localization and the activity of
RhoA and citron K, which are essential for early stages of cytokinesis, are not
dependent on paxillin,
Crk or syntaxin-2
Hanna et al., J Biol Chem 2009
:
Here we have demonstrated that mechanical strain dependent induction of the CCN1 gene involves signaling cascades through
RhoA mediated actin remodeling and the
p38 stress activated protein kinase ( SAPK )
Cariolato et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
Our results indicate that AKAP-Lbc can assemble a novel transduction complex containing the RhoA effector PKNa, MLTK, MKK3, and p38a, which integrates signals from a ( 1b ) -ARs to promote
RhoA dependent activation of
p38a
Chaturvedi et al., Am J Physiol Cell Physiol 2011
(MAP Kinase Signaling System...) :
Role of
RhoA and its effectors ROCK and mDia1 in the modulation of deformation induced FAK, ERK,
p38 , and MLC motogenic signals in human Caco-2 intestinal epithelial cells ... Furthermore,
RhoA , ROCK inhibition or RhoA, ROCK1, ROCK2, and mDia1 reduction by siRNA also
blocked strain induced FAK-Tyr ( 925 ),
p38 , and MLC phosphorylation
Moey et al., J Pharmacol Exp Ther 2011
(Cardiomegaly) :
These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of
p115RhoGEF-RhoA/ROCK dependent
p38 MAPK activation