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BRCA1 — RAD51
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BARD1 signaling events:
BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA)
→
RAD51 (RAD51)
(modification, collaborate)
Scully et al., Cell 1997*
Evidence: assay, physical interaction
-
NCI Pathway Database BARD1 signaling events:
BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA)
→
PCNA (PCNA)
(modification, collaborate)
Scully et al., Cell 1997*
Evidence: assay, physical interaction
-
NCI Pathway Database BARD1 signaling events:
BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA)
→
BRCA1/BARD1 complex (BRCA1-BARD1)
(modification, collaborate)
Scully et al., Cell 1997*
Evidence: assay, physical interaction
-
NCI Pathway Database BARD1 signaling events:
RAD51 (RAD51)
→
BRCA1/BARD1 complex (BRCA1-BARD1)
(modification, collaborate)
Scully et al., Cell 1997*
Evidence: assay, physical interaction
-
Reactome Reaction:
BRCA1
→
RAD51
(direct_complex)
Masson et al., EMBO J 1999, Sehorn et al., Nature 2004, Oliver-Bonet et al., Mol Hum Reprod 2005, Thorslund et al., EMBO J 2007, Oliver-Bonet et al., Mol Hum Reprod 2007, Sheridan et al., Nucleic Acids Res 2008, Okorokov et al., PloS one 2010, Scully et al., Cell 1997, Barlow et al., EMBO J 1997, Golub et al., Nucleic Acids Res 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
BRCA1
—
RAD51
Scully et al., Cell 1997
-
IRef Bind Interaction:
RAD51
—
BRCA1
Scully et al., Cell 1997
-
IRef Bind_translation Interaction:
RAD51
—
BRCA1
(coimmunoprecipitation)
Scully et al., Cell 1997
-
IRef Bind_translation Interaction:
RAD51
—
BRCA1
(affinity chromatography technology)
Scully et al., Cell 1997
-
IRef Bind_translation Interaction:
BRCA1
—
RAD51
(coimmunoprecipitation)
Scully et al., Cell 1997
-
IRef Bind_translation Interaction:
BRCA1
—
RAD51
(affinity chromatography technology)
Scully et al., Cell 1997
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(direct interaction, pull down)
Chen et al., Mol Cell 1998*
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(colocalization, imaging technique)
Mok et al., Cell Signal 2010*
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(physical association, affinity chromatography technology)
Scully et al., Cell 1997
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(direct interaction, pull down)
Scully et al., Cell 1997
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(physical association, affinity chromatography technology)
Dong et al., Mol Cell 2003
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(association, biochemical)
Dong et al., Mol Cell 2003
-
IRef Biogrid Interaction:
BRCA1
—
RAD51
(direct interaction, pull down)
Wang et al., Oncogene 2001*
-
MIPS CORUM BRCA1-RAD51 complex:
BRCA1-RAD51 complex complex (BRCA1-RAD51)
Scully et al., Cell 1997
-
MIPS CORUM BRCC complex:
BRCC complex complex (BRCA1-BRCA2-BRCC3-BRE-RAD51)
Dong et al., Mol Cell 2003
-
IRef Corum Interaction:
Complex of BRCA2-BRCA1-BRCC3-BRE-RAD51
(association, affinity chromatography technology)
Dong et al., Mol Cell 2003
-
IRef Corum Interaction:
RAD51
—
BRCA1
(association, anti bait coimmunoprecipitation)
Scully et al., Cell 1997
-
IRef Dip Interaction:
Complex of BRIP1-PALB2-BRCA2-RBBP8-RAD51-RPA1-BRCA1
(physical association, molecular sieving)
Sy et al., Proc Natl Acad Sci U S A 2009
-
IRef Hprd Interaction:
RAD51
—
BRCA1
(in vivo)
Sarkisian et al., J Biol Chem 2001*, Chen et al., Mol Cell 1998*
-
IRef Hprd Interaction:
RAD51
—
BRCA1
(in vitro)
Sarkisian et al., J Biol Chem 2001*, Chen et al., Mol Cell 1998*
-
IRef Hprd Interaction:
Complex of 26 proteins
Ryser et al., Cancer Res 2009
-
IRef Hprd Interaction:
RAD51
—
BRCA1
(in vivo)
Scully et al., Cell 1997, Chen et al., Mol Cell 1998*
-
IRef Intact Interaction:
Complex of 13 proteins
(colocalization, cosedimentation through density gradient)
Bleuyard et al., EMBO Rep 2012
-
IRef Intact Interaction:
Complex of H2AFX-PALB2-RAD51-MORF4L1-LMNA-BRCA1-BRCA2
(colocalization, cosedimentation through density gradient)
Bleuyard et al., EMBO Rep 2012
-
IRef Intact Interaction:
Complex of MORF4L1-RAD51-BRCA2-BRCA1-PALB2
(association, anti tag coimmunoprecipitation)
Bleuyard et al., EMBO Rep 2012
-
IRef Ophid Interaction:
RAD51
—
BRCA1
(aggregation, confirmational text mining)
Chen et al., Mol Cell 1998*
-
IRef Ophid Interaction:
RAD51
—
BRCA1
(aggregation, confirmational text mining)
Scully et al., Cell 1997
-
IRef Ophid Interaction:
RAD51
—
BRCA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Broustas et al., J Biol Chem 2004
(Prostatic Neoplasms) :
BRCC2 , a novel BH3-like domain containing protein, induces apoptosis in a
caspase dependent manner
Zhou et al., Biochem Biophys Res Commun 2005
(Breast Neoplasms...) :
We found that although a functional BRCA1 is required for the subnuclear assembly of BRCA1 foci following treatment with either ionizing radiation or cisplatin, a functional
BRCA1 is
required for
RAD51 foci to form following treatment with cisplatin but not with ionizing radiation
Cousineau et al., Cancer Res 2005
(Breast Neoplasms...) :
However,
BRCA1 may
regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both ... However,
BRCA1 may
regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both