◀ Back to CTNNB1

CTNNB1 — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → EGFR (directlyIncreases, CTNNB1 Activity)
  Evidence: The binding of beta-catenin to these partners is regulated by phosphorylation of at least three critical tyrosine residues. Each of these residues is targeted by one or more specific kinases: Y142 by Fyn, Fer and cMet; Y489 by Abl; and Y654 by Src and the epidermal growth factor receptor.
• OpenBEL Selventa BEL large corpus: Complex of CTNNB1-EGFR → NRG1 (increases)
  Evidence: HRG treatment also promoted the level of tyrosine-phosphorylated beta -catenin associated with HER2, with a maximum effect detected at 15 min (Fig. 2B, lowest panel).
• BioCarta trefoil factors initiate mucosal healing: TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1) → beta-catenin (CTNNB1) (modification, activates)
• KEGG Adherens junction: EGFR/ERBB2 → CTNNB1 (protein-protein, inhibition)
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, activates)
  Miravet et al., Mol Cell Biol 2003, Hoschuetzky et al., J Cell Biol 1994, Shibamoto et al., Cell adhesion and communication 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: EGFR (EGFR) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, collaborate)
  Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
  Evidence: assay, physical interaction
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → EGFR/EGFR/EGF/EGF complex (EGFR-EGF) (modification, inhibits)
  Qian et al., EMBO J 2004, Hoschuetzky et al., J Cell Biol 1994, Takahashi et al., Exp Cell Res 1996
  Evidence: assay, physical interaction
• NCI Pathway Database E-cadherin signaling in keratinocytes: EGFR (EGFR) → E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) (modification, collaborate)
  Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• NCI Pathway Database E-cadherin signaling in keratinocytes: E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) → EGFR(dimer) complex (EGFR) (modification, activates)
  Pece et al., J Biol Chem 2000, Betson et al., J Biol Chem 2002
  Evidence: assay, physical interaction
• WikiPathways Gastric Cancer Network 2: EGFR → CTNNB1 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — EGFR (direct interaction, pull down) Hazan et al., J Biol Chem 1998
• IRef Biogrid Interaction: CTNNB1 — EGFR (physical association, affinity chromatography technology) Schroeder et al., J Biol Chem 2002*
• IRef Biogrid Interaction: CTNNB1 — EGFR (physical association, affinity chromatography technology) Takahashi et al., Oncogene 1997*
• IRef Hprd Interaction: CTNNB1 — EGFR (in vivo) Takahashi et al., Oncogene 1997*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 24 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Ophid Interaction: CTNNB1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., J Biol Chem 2001 : The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin ... Moreover, in vitro and in vivo studies demonstrate that EGF-R increases binding of MUC1 and beta-catenin ... These findings support a novel role for EGF-R in regulating interactions of MUC1 with c-Src and beta-catenin
Mizushima et al., Cancer Res 2002 (Esophageal Neoplasms) : Although both Wnt and epidermal growth factor inactivate glycogen synthase kinase 3beta, activation of epidermal growth factor receptor did not stabilize beta-catenin
Alvarado et al., Genetics 2004 : Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1
Hiscox et al., Int J Cancer 2006 (Breast Neoplasms) : Inhibition of EGFR kinase activity in TamR cells reduced beta-catenin tyrosine phosphorylation, increased beta-catenin-E-cadherin association and promoted cell-cell adhesion
Lin et al., FEBS Lett 2006 (Carcinoma, Hepatocellular...) : Furthermore, inhibition of the epidermal growth factor receptor (EGFR) with gefitinib partially prevented the downregulation of E-cadherin and beta-catenin at the adherens junctions and migration behavior induced by RAW/AMCM
Rosanò et al., Proc Natl Acad Sci U S A 2009 (Neoplasm Invasiveness...) : We then demonstrate that silencing of both beta-arrestin-1 and beta-arrestin-2 inhibits ET ( A ) R-driven signaling, causing suppression of Src, mitogen activated protein kinase ( MAPK ), AKT activation, as well as EGFR transactivation and a complete inhibition of ET-1 induced beta-catenin/TCF transcriptional activity and cell invasion
Lee et al., Molecular cancer 2010 (Mouth Neoplasms) : We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of beta-catenin in the nuclei of oral cancer cells ... TOP-FLASH and FOP-FLASH reporter assays demonstrated that the EGFR signal regulates beta-catenin transcriptional activity and mediates cyclin D1 expression
Hoschuetzky et al., J Cell Biol 1994 : Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor