Daniels et al., Brain Res 2003
(MAP Kinase Signaling System) :
Subsequent experiments revealed that the effect of MTII on MAPK activation in MC4-R transfected cells was dose dependent and was maximal after 10 min of MTII exposure
Scarpi et al., Cell death & disease 2012
:
Like NGF, MT2 increased phosphorylation of extracellular signal regulated kinase1/2 and Akt proteins and production of MKP-1 phosphatase ( dual specificity phosphatase 1 ), modulated p38 mitogen activated protein kinase activation, sustained survival of serum starved PC12 or RDG cells, and promoted their differentiation