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MAPK4 — UCN
Text-mined interactions from Literome
Grammatopoulos et al., Mol Endocrinol 2000
(MAP Kinase Signaling System) :
We therefore hypothesized that activation of
MAPK might
mediate CRH and
or/urocortin actions in the myometrium ... The R1alpha and R2beta, but not the R1beta, R1c, or R1d, receptor subtypes were able to mediate
urocortin induced
MAPK activation ... In conclusion,
UCN acting thought multiple receptor subtypes can
stimulate myometrial
MAPK via induction of the Gq/phospholipase C/IP3/PKC pathway, whereas CRH induced activation of this pathway appears to be insufficient to achieve MAPK activation
Dai et al., Cancer Res 2001
(Leukemia...) :
Coadministration of the MEK inhibitor PD184352 ( 10 microM ) blocked
UCN-01 induced
MAPK activation and was accompanied by marked mitochondrial damage ( e.g., cytochrome c release and loss of DeltaPsi ( m ) ), caspase activation, DNA fragmentation, and apoptosis
Schulman et al., Am J Physiol Heart Circ Physiol 2002
(Hypotension...) :
Urocortin attenuated lethal reperfusion induced injury both in vitro and in vivo via a p42/p44
MAPK dependent mechanism
McKinstry et al., Cancer Biol Ther 2002
(Breast Neoplasms...) :
Inhibition of MEK1/2 caused modest reductions in basal MAPK activity and transiently suppressed
UCN-01 stimulated
MAPK activity below that of MEK1/2 inhibitor alone
Punn et al., Mol Endocrinol 2006
:
In human embryonic kidney 293 cells overexpressing recombinant CRH-R1alpha,
UCN I
induced ERK1/2 and p38
MAPK activation was dependent on signaling molecules involved in agonist induced CRH-R1alpha trafficking and endocytosis ...
UCN I
effect on p38
MAPK phosphorylation was more transient, returned to basal within 40 min and was dependent on epidermoid growth factor receptor transactivation, but not PI3-K/Akt activation