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EGR1 — JUN

Pathways - manually collected, often from reviews:

• FastForward regulation: EGR1 → JUN (transcriptional regulation, decrease) Faour et al., J Biol Chem 2005*
  Evidence: REG

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: EGR1 — JUN (in vitro) Verger et al., J Biol Chem 2001*
• IRef Hprd Interaction: EGR1 — JUN (in vivo) Verger et al., J Biol Chem 2001*
• IRef Innatedb Interaction: EGR1 — JUN (unknown, -) Kubosaki et al., Genome Biol 2009
• IRef Ophid Interaction: EGR1 — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Levkovitz et al., J Neurosci 2001 : Furthermore, the Egr inhibitor blocks the ability of MEKK1 [ mitogen activated protein kinase ( MAPK ) kinase kinase 1 ], an upstream kinase capable of stimulating the JNK ( c-Jun N-terminal protein kinase ) -c-Jun pathway, to induce apoptosis and activate c-Jun
Levkovitz et al., J Neurosci 2002 : A dominant negative Egr inhibitor blocks nerve growth factor induced neurite outgrowth by suppressing c-Jun activation : role of an Egr/c-Jun complex
Faour et al., J Biol Chem 2005 (Arthritis, Rheumatoid) : PGE2 suppression of IL-17 induced ATF-2/c-Jun transactivation and DNA binding was dependent on Egr-1 mediated inhibition of induced c-Jun expression
Mizuochi et al., Translational research : the journal of laboratory and clinical medicine 2007 : Carvedilol inhibited both expression of early growth response factor-1 (Egr-1) and phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, but it did not inhibit activation of either nuclear factor-kappaB or activator protein-1 in monocytes stimulated with LPS
Hoffmann et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Reconstitution experiments in c-Jun-deficient cells revealed that c-Jun is required for EGR-1 transcription through both the AP-1 site and the distal SREs
Sabuda-Widemann et al., Nephrol Dial Transplant 2009 : MPA was tested on the expression of platelet derived growth factor-B ( PDGF-B ) and its receptor beta ( PDGFR-beta ), the immediate early gene ( IEG ) c-fos and the early growth response gene-1 (Egr-1) , and AP-1 activation
Ni et al., J Biol Chem 2010 (Hyperplasia) : c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins ... Injury- and shear-inducible c-Jun controls early growth response-1
Song et al., Neuroreport 2012 : However, our data show that neither suppressing Egr activity using a dominant negative mutant nor specifically silencing Egr-1 using small interfering RNA inhibited the activation and expression of c-Jun after activity deprivation in cerebellar granule neurons