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ANGPT2 — TIE1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Fujiyama et al., Circ Res 2001
:
We tested the
effects of
Ang II on Ang1, Ang2, or
Tie2 expression in cardiac microvascular endothelial cells expressing the Ang II receptors AT(1) and AT(2)
Yu et al., Am J Pathol 2001
(Hemangioma) :
Increased
Tie2 expression,
enhanced response to angiopoietin-1, and dysregulated
angiopoietin-2 expression in hemangioma derived endothelial cells
Christensen et al., J Cell Biochem 2002
:
Hypoxia induced expression of NERF2 and
Tie2 was
blocked by
angiopoietin-2 , a competitive inhibitor of angiopoietin-1, and by recombinant soluble extracellular domain of Tie2 but not by VEGF neutralizing antibodies
Gale et al., Dev Cell 2002
(Chylous Ascites...) :
While Angiopoietin-1 obligately activates its Tie2 receptor,
Angiopoietin-2 can
activate Tie2 on some cells, while it blocks Tie2 activation on others
Fiedler et al., J Biol Chem 2003
:
Collectively, the data show that the first 104 amino acids of the
Tie-2 receptor are
essential but not sufficient for
angiopoietin binding
Wulff et al., Reproduction 2003
(Neovascularization, Pathologic...) :
It is hypothesized that VEGF/VEGF-R1 and Ang-1/Tie receptor 2 (Tie-2) may regulate trophoblast differentiation and invasion ; VEGF/VEGF-R2 and
Ang-1/Tie-2 may promote fetoplacental vascular development and stabilization ; and
Ang-2/Tie-2 may be
involved in maternal vascular remodelling
Torimura et al., J Hepatol 2004
(Carcinoma, Hepatocellular...) :
Angiopoietin-1 and
Angiopoietin-2 were
detected in hepatoma cells, hepatic stellate cells, and smooth muscle cells, whereas
Tie-2 was detected in endothelial cells, hepatic stellate cells and smooth muscle cells
Scharpfenecker et al., J Cell Sci 2005
:
The largely complementary phenotypes of Ang-1-deficient mice and Ang-2 overexpressing mice have led to an antagonistic model in which Ang-1 acts as
Tie-2 activating agonist and
Ang-2 acts as a Tie-2 inhibiting antagonist
Takazawa et al., Kidney Int 2005
(Glomerulonephritis...) :
At the early stage ( day 6 ), glomerular expression of VEGF and receptors flk-1 and flt-1 as well as Ang-1, and receptor
Tie2 were increased, and glomerular monocyte infiltration and the expression of
angiopoietin-2 (Ang-2) , a natural antagonist of Ang-1, were
reduced
Bogdanovic et al., J Cell Sci 2006
:
Activation of
Tie2 by angiopoietin-1 and
angiopoietin-2 results in their release and receptor internalization
Daly et al., Proc Natl Acad Sci U S A 2006
:
In addition, we show that
Ang-2 , like Ang-1,
activates Tie2/Akt signaling in vivo, thereby inhibiting the expression of FOXO1 target genes
Findley et al., Arterioscler Thromb Vasc Biol 2007
:
sTie2 bound both Ang1 and Ang2 and inhibited
angiopoietin mediated
Tie2 phosphorylation and antiapoptosis
Yacyshyn et al., Angiogenesis 2009
:
siRNA silencing of HPTPbeta enhanced Ang-1 and
Ang-2 induced
Tie2 phosphorylation at 10 min ( 2.5-fold, P < 0.001 ; and 1.8-fold, P < 0.05, respectively )
van der Heijden et al., Shock 2010
(Acute Lung Injury...) :
Soluble
Tie2 did not
affect the association between Ang-1 or
Ang-2 and the PLI ( beta = -0.39, P < 0.001 ; beta = 0.52, P < 0.001, respectively ), independently of underlying disease
Hansen et al., Cell Signal 2010
:
This differential regulation of
angiopoietin binding
allows control of
Tie2 activation response to Ang1 without affecting Ang2 agonist activity and maintains the ability of Ang2 to antagonize even the enhanced Ang1 activation of Tie2 that occurs on loss of Tie1 ectodomain
Seegar et al., Mol Cell 2010
:
To address the
role of
Tie1 in
angiopoietin mediated Tie2 signaling and determine the basis for the behavior of the individual angiopoietins, we used an in vivo FRET based proximity assay to monitor Tie1 and -2 localization and association ... Based on the available data, we propose a unified model for
angiopoietin induced
Tie2 signaling
Chen et al., Am J Physiol Heart Circ Physiol 2012
(Diabetes Mellitus...) :
Overexpression of
Ang-2 suppressed
Tie-2 and VEGF expression in db/db mouse hearts together with significant upregulation of Wnt7b expression
Pietilä et al., J Cell Sci 2012
:
Ligand oligomerization state controls
Tie2 receptor trafficking and
angiopoietin-2-specific responses
Felcht et al., J Clin Invest 2012
(Melanoma...) :
These data establish a contextual model whereby differential
TIE2 and integrin expression, binding, and activation
control the role of
ANG-2 in angiogenesis
Benest et al., PloS one 2013
:
Angiopoietin-2 (Ang-2) acts on
Tie2 expressing resting endothelial cells as an antagonistic ligand to negatively interfere with the vessel stabilizing effects of constitutive Ang-1/Tie-2 signaling