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EGF — TNK2

Pathways - manually collected, often from reviews:

• WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)
  

Text-mined interactions from Literome

Kato-Stankiewicz et al., Biochem Biophys Res Commun 2001 : Specific inhibition of the interaction of ACK1 with Cdc42 or Grb2 by the use of these constructs diminished tyrosine phosphorylation of both ACK1 and Dbl in response to EGF ... In addition, we show that EGF transiently induces formation of the focal complex and stress fibers when ACK1 was ectopically expressed
Chan et al., J Biol Chem 2009 (Neoplasm Metastasis...) : Because EGF stimulation activates ACK1 ( Galisteo, M., Y., Y., Urena, J., and Schlessinger, J. ( 2006 ) Proc. Natl. Acad. Sci. U. S. A. 103, 9796-9801 ), our result suggest that EGF receptor mediated ACK1 activation allows Nedd4-2 to drive kinase degradation