UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to LY96

LY96 — TIRAP

Pathways - manually collected, often from reviews:

BioCarta toll-like receptor pathway: CD14 → LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) (modification, collaborate)
BioCarta toll-like receptor pathway: CD14 → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta toll-like receptor pathway: None → LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) (modification, collaborate)
BioCarta toll-like receptor pathway: None → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) → CD14/LBP complex (CD14-EHHADH) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: None → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: CD14/LBP complex (CD14-EHHADH) → TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2) (modification, collaborate)
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages: LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14) (ceramide biosynthetic process, activates)
BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TRAF6 (modification, activates)
NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK2 (IRAK2) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → IRAK4 (IRAK4) (modification, collaborate) Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → IRAK (IRAK1) (modification, collaborate) Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK4 (IRAK4) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: IRAK (IRAK1) → HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP) (modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HSPD1-MYD88-TIRAP) → HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) (modification, collaborate)
Cohen-Sfady et al., J Immunol 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HSPD1-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Cohen-Sfady et al., J Immunol 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Cohen-Sfady et al., J Immunol 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP) → BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: MYD88/TIRAP complex (MYD88-TIRAP) → BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer) complex (TLR4-LY96-S100A8-S100A9) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Vogl et al., Nat Med 2007
Evidence: assay
NCI Pathway Database Endogenous TLR signaling: BGN/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-BGN-MYD88-TIRAP) → BGN/TLR4/MD2 (dimer) complex (TLR4-LY96-BGN) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: BGN/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-BGN-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: BGN/TLR4/MD2 (dimer) complex (TLR4-LY96-BGN) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → HMGB1/TLR4/MD2 (dimer) complex (TLR4-LY96-HMGB1) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: HMGB1/TLR4/MD2 (dimer) complex (TLR4-LY96-HMGB1) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
NCI Pathway Database Endogenous TLR signaling: MRP8/MRP14/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-MYD88-TIRAP-S100A8-S100A9) → IRAK (IRAK1) (modification, activates) Vogl et al., Nat Med 2007
Reactome Reaction: LY96 → TIRAP (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Yamamoto et al., Nature 2002, Horng et al., Nature 2002, Jefferies et al., J Biol Chem 2003, Kollewe et al., J Biol Chem 2004, Gray et al., J Biol Chem 2006, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Núñez Miguel et al., PloS one 2007 *, Piao et al., J Biol Chem 2008, Kawagoe et al., Nat Immunol 2008, Verstak et al., J Biol Chem 2009 *
Reactome Reaction: LY96 → TIRAP (indirect_complex) Yamamoto et al., Nature 2002, Horng et al., Nature 2002, Jefferies et al., J Biol Chem 2003, Brunner et al., Histol Histopathol 2005, Gray et al., J Biol Chem 2006, Núñez Miguel et al., PloS one 2007 *, Piao et al., J Biol Chem 2008, Verstak et al., J Biol Chem 2009 *, Lee et al., Proc Natl Acad Sci U S A 2012