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NFKB1 — PRKAB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Cacicedo et al., Biochem Biophys Res Commun 2004
:
AMPK inhibits fatty acid induced increases in
NF-kappaB transactivation in cultured human umbilical vein endothelial cells ... The increases in
NF-kappaB activation and VCAM-1 expression caused by palmitate were markedly
inhibited by co-incubation with the AMPK activator AICAR and, where studied, by expression of a constitutively active
AMPK ... Likewise,
AMPK activation
inhibited the increase in
NF-kappaB reporter gene expression observed in HUVEC incubated with TNF-alpha ... The results suggest that
AMPK inhibits the activation of
NF-kappaB caused by both palmitate and TNF-alpha
Hattori et al., Hypertension 2006
:
A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ), dose-dependently
inhibited TNF-alpha- and interleukin-1beta induced
NF-kappaB reporter gene expression ... In light of these findings, we suggest that metformin attenuates the cytokine induced expression of proinflammatory and adhesion molecule genes by inhibiting
NF-kappaB activation via
AMPK activation
Jhun et al., Biochem Biophys Res Commun 2006
:
Moreover, inhibition of
AMPK suppressed transcriptional activation of NF-AT and AP-1, but not
NF-kappaB , in PMA/Io activated Jurkat cells
Li et al., J Cell Biochem 2007
(Cardiomegaly...) :
Furthermore, long-term
AMPK activation
attenuated protein synthesis, diminished calcineurin-nuclear factor of activated T cells ( NFAT ) and
nuclear factor kappaB (NF-kappaB) signaling in pressure overload induced hypertrophic hearts ... Our in vitro experiments further proved that activation of
AMPK by infection of AdAMPK
blocked cardiac hypertrophy and NFAT,
NF-kappaB , and MAPK signal pathways
Yoon et al., Biochem Biophys Res Commun 2008
(Glioma) :
Finally, we showed that inhibition of
AMPK reduced DNA binding and transcriptional activation of
nuclear factor-kappaB (NF-kappaB) in KA-treated cells
Hattori et al., FEBS Lett 2008
:
HMW adiponectin by itself was found to modestly activate
NF-kappaB , which was significantly
enhanced by inhibition of
AMPK/eNOS activation
Wang et al., J Cell Physiol 2010
(Cardiomegaly) :
Pharmacological activator of
AMPK could inhibit AngII induced NF-kappaB translocation, and inhibitor of AMPK or a dominant negative AMPK adenovirus
suppressed gAd mediated inhibition of I-kappaB phosphorylation and
NF-kappaB activation ... Our data indicate that gAd inhibits cardiac hypertrophic signaling through
AMPK mediated suppression of
NF-kappaB activation
Łabuzek et al., Neurotoxicology 2010
:
Furthermore, we found that the effects of AICAR on IL-6 and TNF-alpha ( 12, 24h ) release and on the expression of iNOS and
NF-kappaB p65 are not
AMPK dependent because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010
(Inflammation) :
However, compound C down-regulated IL-1 beta, IL-6 and TNF alpha release, NO, ROS production, and
AMPK activity,
diminished NF-kappaB and HIF-1 alpha expression, as well as increased arginase I expression in lipopolysaccharide (LPS) stimulated microglia
Wang et al., Circ Res 2010
:
Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of
AMPK activity
increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ), NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of
NF-kappaB ( p50 and p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect
Liu et al., J Biol Chem 2010
:
Furthermore,
AMPK activation significantly
enhanced IkappaBalpha kinase activation, NF-kappaB nuclear translocation, and DNA binding activity of
NF-kappaB
Yang et al., J Biol Chem 2010
(Insulin Resistance...) :
Chromatin immunoprecipitation and luciferase reporter assays show that activation of
AMPK by CA-alpha1 in macrophages significantly
inhibits LPS- or FFA induced
NF-kappaB signaling
Hattori et al., Diabetologia 2010
:
Liraglutide induced enhancement of nitric oxide production and suppression of
NF-kappaB activation were
attenuated by the AMP activated protein kinase (AMPK) inhibitor compound C or
AMPK ( also known as PRKAA1 ) small interfering RNA