◀ Back to HDAC1
HDAC1 — SUMO1
Pathways - manually collected, often from reviews:
-
BioCarta sumoylation by ranbp2 regulates transcriptional repression:
RanBP2 (RANBP2)
→
SUMO1/HDAC complex (SUMO1-HDAC1)
(modification, activates)
-
BioCarta sumoylation by ranbp2 regulates transcriptional repression:
SUMO1/HDAC complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin/HDAC complex (RAN-HDAC1)
(modification, collaborate)
-
BioCarta sumoylation by ranbp2 regulates transcriptional repression:
SUMO1/HDAC complex (SUMO1-HDAC1)
→
SUMO-1 (SUMO1)
(modification, collaborate)
-
BioCarta sumoylation by ranbp2 regulates transcriptional repression:
SUMO1/HDAC complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin complex (RAN)
(modification, collaborate)
-
BioCarta sumoylation by ranbp2 regulates transcriptional repression:
Ran/GTP/Exportin/HDAC complex (RAN-HDAC1)
→
SUMO-1 (SUMO1)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SUMO1 (SUMO1)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1 complex (RAN-XPO1)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
SUMO1/HDAC1 complex (SUMO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, activates)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1/HDAC1 complex (SUMO1-HDAC1)
→
SUMO1 (SUMO1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1/HDAC1 complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin 1 complex (RAN-XPO1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1/HDAC1 complex (SUMO1-HDAC1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
-
NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression:
SUMO1 (SUMO1)
→
Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1)
(modification, collaborate)
David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
Evidence: assay
Text-mined interactions from Literome
Novatchkova et al., BMC bioinformatics 2005
:
Recent findings point at the importance of
SUMO mediated
histone NAD dependent deacetylase (HDAC) recruitment in transcriptional regulation
Yang et al., EMBO J 2005
:
However, in the basal state, its activity is repressed by
SUMO dependent
histone deacetylase (HDAC) recruitment
Park et al., Nucleic Acids Res 2008
:
Consistently, silencing of
SUMO1 led to recruitment of BRCA1 and release of
HDAC1 at the BRCA1 target promoters, and subsequent transcriptional activation of the BRCA1 target genes
Molvaersmyr et al., Nucleic Acids Res 2010
:
Thus, c-Myb harbours two AFs, one that is constitutively active and one in the
NRD being
SUMO regulated ( SRAF )