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HGF — MMP8
Text-mined interactions from Literome
Hamasuna et al., Int J Cancer 1999
(Brain Neoplasms...) :
MT1
-MMP , a cell-surface activator of proMMP-2, was also
up-regulated by
HGF/SF in a dose dependent manner
Hanzawa et al., Carcinogenesis 2000
(Carcinoma, Squamous Cell...) :
Here we examined the
effect of
HGF on E1AF and
MMP gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3
Wang et al., Biochem Biophys Res Commun 2000
(MAP Kinase Signaling System) :
Hepatocyte growth factor enhances
MMP activity in human endothelial cells
Imafuku et al., Clin Chim Acta 2002
:
We also found a definite effects on copper, angiotensin converting enzyme (ACE),
matrix metalloproteinase (MMP)-1 , -3 and -9, tissue
inhibitor of matrix metalloproteinase ( TIMP ) -1,
hepatocyte growth factor (HGF) , monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6, though the mechanisms were not clear
Hirata et al., Biol Reprod 2003
:
Membrane type-1
MMP mRNA expression in the stromal cells was
augmented by tumor necrosis factor alpha (TNFalpha), IL-6,
HGF , and 12-O-tetradecanoylphorbol 13-acetate
Fujiuchi et al., Oncol Rep 2003
(Neoplasm Invasiveness...) :
Furthermore,
HGF also
increased the production of MMP-1 and -9,
MT1-MMP , u-PA and uPAR of these cells
Li et al., World J Gastroenterol 2005
(Colorectal Neoplasms...) :
Compared with controls,
MMP-2 and MMP-9 mRNA expressions were
up-regulated by
HGF ( 0.997+/-0.011 vs 1.207+/-0.003, t = 35.002,P = 0.001 < 0.01 ; 0.387+/-0.128 vs 0.971+/-0.147, t = 106.036, P = 0.0000 < 0.01, respectively ) ; compared with controls, TIMP-1, TIMP-2 mRNA expressions were increased by PD98059 ( 1.344+/-0.007 vs 1.905+/-0.049, t = 17.541, P = 0.003 < 0.01 ; 1.286+/-0.020 vs 1.887+/-0.022,t = 24.623, P = 0.002 < 0.01, respectively )
Ide et al., Int J Cancer 2006
(Neoplasm Invasiveness...) :
Conversely, the elevated cancer invasion,
MMP activity and c-Met phosphorylation of PK8 cells were
reduced by the removal of
HGF from hypoxic conditioned medium
Aparicio et al., C R Seances Soc Biol Fil 1998
(Colonic Neoplasms...) :
After 24 or 48 h of culture in medium supplemented with HGF, transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate,
MMP production by DHD/K12 cells was
stimulated by
HGF and TGF-alpha and inhibited by sodium butyrate