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IL1RN — MAPK9
Text-mined interactions from Literome
Zieker et al., Physiol Genomics 2005
:
In line with the results of former studies, we observed an upregulation of
mitogen activated protein kinase activated protein kinase-2 ( MAPKAP-K2 ), L-selectin, and
IL-1 receptor antagonist (IL-1ra) after exhaustive exercise
Zheng et al., Acta Pharmacol Sin 2006
(Arthritis, Experimental) :
The increased phosphorylation of
MAPK and cell proliferation in fibroblast-like synoviocytes ( FLS ) stimulated by supernatants of MLS in AA rats was also
inhibited by
IL-1ra ( 10 and 40 mg/kg, ic, d 14-21 )
Sung et al., Acta Anaesthesiol Taiwan 2007
(Hyperalgesia) :
I.t. pretreatment of
IL-1 receptor antagonist (IL-1ra) , p38
MAPK inhibitor or iNOS inhibitor, inhibits the i.t. IL-1beta induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain