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IRF6 — PPARG

Text-mined interactions from Literome

Von Knethen A et al., FASEB J 2001 : Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages ... Taking the anti-inflammatory properties of the peroxisome proliferator activating receptorgamma ( PPARgamma ) into consideration, we established activation of PPARgamma in response to LPS/IFN-gamma by an electrophoretic mobility shift, supershift, and a reporter gene assay
Simonin et al., Am J Physiol Cell Physiol 2002 : A decrease in PPAR-gamma expression induced by 10 microg/ml lipopolysaccharide (LPS) was observed, whereas PPAR-alpha mRNA expression was not modified
Hinz et al., Biochem Biophys Res Commun 2003 (Inflammation) : Stimulation of monocytes with LPS resulted in an 88 % inhibition of PPAR-gamma mRNA expression that was fully restored by 15d-PGJ ( 2 ) but only to a partial extent by ciglitazone and WY-14,643 ... Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ ( 2 )
Mrácek et al., Cytokine 2004 : IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes
Kim et al., Immunol Cell Biol 2007 : Moreover, LPS itself reduced the expression of PPARgamma
Zhang et al., Am J Nephrol 2006 : Stimulation of RPMCs with LPS resulted in a time dependent increase in the expression of PPARgamma with the peak of mRNA at 3 h and protein at 12 h
Andersson et al., J Cyst Fibros 2008 (Cystic Fibrosis...) : This was associated with low basal PPARgamma expression and attenuated LPS induced induction of PPARdelta, LXRalpha and ABCA1
Necela et al., Immunology 2008 : Lipopolysaccharides (LPS) , which activate Toll-like receptor 4 (TLR4), reduced PPARgamma expression and function in peritoneal macrophages and macrophage cell lines ... Moreover, pretreatment with the synthetic PPARgamma ligand, rosiglitazone did not prevent LPS mediated downregulation of PPARgamma ... Inhibition of PPARgamma expression was not blocked by cycloheximide, indicating that de novo protein synthesis is not required for LPS mediated suppression of PPARgamma ... LPS had no effect on PPARgamma expression in macrophages from TLR4 knockout mice, whereas LPS inhibited PPARgamma expression in cells that had been reconstituted to express functional TLR4 ... However, inhibitors that target NEMO, IkappaB and NF-kappaB abolished LPS mediated downregulation of PPARgamma in LPS stimulated macrophages
Liu et al., Vet J 2010 : LPS also induced an increase in PPARgamma immunohistochemical staining in the hypothalamus ( 1.3-fold ), adenohypophysis ( 1.3-fold ), adrenal cortex ( 1.4-fold ) and adrenal medulla ( 1.6-fold ) ( P < 0.05 )
Jennewein et al., J Biol Chem 2010 : LPS significantly reduced luciferase activity of the pGL3-PPARgamma-3'-UTR , suggesting that PPARgamma1 mRNA is destabilized