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CD34 — IL7

Text-mined interactions from Literome

Drouet et al., Stem Cells 2001 : We showed in a nonhuman primate model of autologous peripheral blood stem and progenitor cell transplantation that cell cycle activation of CD34 ( + ) cells in the presence of stem cell factor + FLT3-ligand + thrombopoietin + interleukin 3 ( six days of culture ) which induced G1 and S/G2/M cell amplification ( G0 : 6.1 % +/- 2.8 % ; G0/G1 : 64.2 % +/- 7.2 % ; S/G2/M : 30.4 % +/- 7.3 % respectively of expanded CD34 ( + ) cells on average ) resulted in the acceleration of short-term granulocyte recovery
Vellenga et al., J Immunol 1992 : In addition, it was shown that CD34+ sorted cells could be stimulated by IL-7 ( 0 vs 15 +/- 9 CFU-Eo/3 x 10 ( 3 ) CD34+ cells ) Furthermore studies with IL-3 or granulocyte-macrophage CSF (GM-CSF) demonstrated an additive effect on the IL-7 supported colony formation