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CDH2 — EGF
Text-mined interactions from Literome
Diamond et al., J Cell Sci 2008
(Carcinoma, Squamous Cell...) :
Unexpectedly, we found that
EGF blocked TGFbeta1 mediated
N-cadherin expression in oral keratinocytes and not in OSCC cells ... The
effect of
EGF on TGFbeta1 mediated Smad-driven promoter activity and
N-cadherin expression was reversed when activation of ERK1/2 was blocked
Smith et al., American journal of physiology. Renal physiology 2009
:
Quantitative RT-PCR and a luciferase reporter assay suggested that
sHB-EGF repressed transcription of
E-cadherin , and a concomitant TGF-beta independent upregulation of the E-cadherin repressor Snail-2 was observed
Cheng et al., PloS one 2012
(Cystadenocarcinoma, Serous...) :
However,
EGF induced down-regulation of E-cadherin and concurrent up-regulation of
N-cadherin in SBOT cells but not in LGC cells ... The PI3K inhibitor LY294002 had similar effects, but it could not block the
EGF induced up-regulation of
N-cadherin and ZEB1
Cheng et al., Oncogene 2013
(Ovarian Neoplasms) :
These two signaling pathways contribute to the
EGF induced downregulation of
E-cadherin , which subsequently increases the invasive capability of ovarian cancer cells
Cheng et al., J Clin Endocrinol Metab 2012
:
Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated
EGF induced Slug expression and the down-regulation of
E-cadherin , as well as subsequent cell invasion