Gene interactions and pathways from curated databases and text-mining

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CASP8 — IL1RN

Text-mined interactions from Literome

Maedler et al., Proc Natl Acad Sci U S A 2004 (Diabetes Mellitus, Type 2) : Antagonizing IL-1Ra by introduction of small interfering RNA to IL-1Ra into human islets led to caspase-3 activation, DNA fragmentation, and impaired beta cell function
Taylor et al., AIDS 2010 (HIV Infections) : Furthermore, Casp8p41 expression in primary CD4 T cells results in increased production of interleukin (IL)-2, IL-15 and tumor necrosis factor (TNF), as well as IL-1RA ; whereas levels of granulocyte macrophage colony stimulating factor and interferon (IFN)-gamma were reduced in the Casp8p41 expressing cells
Maron-Gutierrez et al., Eur Respir J 2011 (Pulmonary Fibrosis...) : Nevertheless, caspase-3 , IL-1ß, IL-1a, IL-1RN and TGF-ß mRNA expression diminished after cell therapy