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EEF1A2 — NOS3

Text-mined interactions from Literome

Brouet et al., Circ Res 2001 : Using geldanamycin, an inhibitor of hsp90 function, and overexpression of recombinant hsp90, we documented that the statin induced phosphorylation of eNOS on Ser1177 was directly dependent on the ability of hsp90 to recruit Akt in the eNOS complex
Harris et al., Am J Physiol Heart Circ Physiol 2004 : However, the mechanism of acute statin stimulated eNOS activation is unknown
Sen-Banerjee et al., Circulation 2005 : Here we report that statin induced expression of endothelial NO synthase (eNOS) and thrombomodulin is KLF2 dependent ... Taken together, these observations indicate that statin dependent induction of eNOS and thrombomodulin requires KLF2 and thereby provides a novel molecular target for modulating endothelial function in vascular disease
Gan et al., Biochem Biophys Res Commun 2006 : This mevastatin mediated antagonism was completely abolished by geranylgeranylpyrophosphate, suggesting that geranylgeranyl modification is needed to activate the eNOS mRNA destabilizing factor -- a mechanism responsible for statin mediated eNOS upregulation
Uchiyama et al., Atherosclerosis 2006 : A decoy oligonucleotide encoding the heat shock element inhibited statin induced expression of heat shock protein 70, endothelial nitric oxide synthase , and thrombomodulin
Uchiyama et al., Atherosclerosis 2007 (Cardiovascular Diseases) : In parallel studies, we found that statin induces the nuclear translocation of HSF1 and that a decoy oligonucleotide encoding the heat shock element inhibits the statin induced expression of heat shock protein 70, endothelial nitric oxide synthase (eNOS) and thrombomodulin
Tousoulis et al., Int J Cardiol 2008 (Atherosclerosis) : Recent evidence suggests that statin treatment induces the expression of eNOS in vascular endothelium, leading to a respective improvement of endothelial function
Merla et al., Am J Physiol Heart Circ Physiol 2007 : The central role of adenosine in statin induced ERK1/2, Akt, and eNOS phosphorylation
Balakumar et al., J Mol Cell Cardiol 2012 (Cardiovascular Diseases) : The upregulation of eNOS by statins is mediated through inhibition of synthesis of isoprenoids and subsequent prevention of isoprenylation of small GTPase Rho, whereas statin induced activation of eNOS is mediated through activation of phosphotidylinositol-3-kinase (PI3K)/protein kinase B ( PKB/Akt ) signals
Li et al., Acta Pharmacol Sin 2012 (Myocardial Infarction...) : The aim of this study was to examine whether protein kinase A (PKA) was involved in statin mediated eNOS phosphorylation and cardioprotection
McLean et al., Arterioscler Thromb Vasc Biol 2012 : We found that statin mediated induction of Kruppel-like factor 2, endothelial nitric oxide synthase , and thrombomodulin expression, as well as inhibition of monocyte-endothelial adhesion, was abrogated by concurrent apelin knockdown
Mashimo et al., J Atheroscler Thromb 2013 : Although it has been reported that -786 T/C polymorphism of the promoter region has an important influence on statininduced transcription of the human eNOS gene, much remains unclear about statin induced eNOS transcription