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RAC3 — ROCK2
Text-mined interactions from Literome
Thirone et al., Am J Physiol Cell Physiol 2009
:
Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not
DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and
CA-ROCK but not CA-Rac and CA-PAK
induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Zong et al., J Biol Chem 1999
:
Rac to Rho point mutations ( V85D or A88D ) within loop 6 of Rac
promoted its association with PRK2 and
ROCK , whereas the reciprocal Rho ( D87V/D90A ) double mutant significantly reduced effector binding capacity