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CDC25C — CDK2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Blomberg et al., Mol Cell Biol 1999
:
In vitro,
Cdc25A dephosphorylates and
activates the
cyclin-Cdk complexes that are active during G ( 1 )
Cangi et al., J Clin Invest 2000
(Breast Neoplasms) :
Furthermore, in the breast cancer cell line MCF-7,
Cdc25A activity is
necessary for both the activation of
Cdk2 and the subsequent induction of S-phase entry
Landrieu et al., J Biol Chem 2001
:
We thus propose that the full
cyclin dependent kinase complex
stimulates the phosphorylation of
CDC25 through binding of its p13 ( SUC1 ) module to the phosphoepitope of the substrate and that the reported WW antagonism of p13 ( SUC1 ) -stimulated CDC25 phosphorylation is caused by competitive binding of both protein modules to the same phosphoepitope
Park et al., Genesis 2003
:
These results suggest that Drosophila
Cdc25 may directly or indirectly
increase the kinase activity of
Cyclin E-Cdk2 complexes in vivo, thus driving arrested neuroblasts into cell division
Major et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
Likewise,
Cdc25B mediated stimulation of
Cdk activity together with elevated levels of the CBP coactivator protein provided a 6.2-fold synergistic increase in FoxM1B transcriptional activity
Boutros et al., Biol Cell 2011
:
CDC25 ( cell division cycle 25 ) phosphatases function as
activators of
CDK ( cyclin dependent kinase ) -cyclin complexes to regulate progression through the CDC