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IGF2 — TNF

Text-mined interactions from Literome

Meadows et al., J Cell Physiol 2000 (Second Messenger Systems) : All treatments suppressed IGF-II production but only TNF-alpha blocked IGFBP-5 secretion
Shalita-Chesner et al., Mol Cell Endocrinol 2001 : This effect was associated with significant reductions in the levels of IGF-l-R mRNA and protein, and with inhibition of IGF-l-R promoter activity, suggesting that TNF-alpha and IFN-gamma affect IGF-l-R gene expression at the transcriptional level
Anwar et al., Circulation 2002 (Arteriosclerosis) : Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle
Garrouste et al., Cell Death Differ 2002 : Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Liu et al., Pediatr Res 2003 : Furthermore, IGF-I inhibited apoptosis of CB DC and increased the production of tumor necrosis factor alpha (TNF-alpha)
Moylan et al., Am J Physiol Cell Physiol 2008 : TNF increases AKT phosphorylation ( +50 % ) and stimulation of AKT with IGF does not prevent TNF induction of atrogin mRNA
Sukhanov et al., FEBS Lett 2011 (Atherosclerosis) : On the contrary, IGF-1 decreased oxidative stress and suppressed TNF-a levels and these effects were blocked by l-NAME
Gude et al., Growth Horm IGF Res 2012 : TNF-a reduced IGF-I and IGF-II protein levels to 51±8 % and 69±8 %, respectively ( P=0.002 ), without affecting mRNA levels ... The secretion of IGF-I is affected by GH, IL-1ß and TNF-a, whereas IGF-II is affected by TNF-a only
Gómez-Hernández et al., Endocrinology 2013 : Thereby, IGF-II or TNF-a induced IRA and IGF-I receptor (IGF-IR) overexpression as well as an increase of IRA/IGF-IR hybrid receptors in VSMCs ... Finally, our data suggest that the IRA isoform and its association with TNF-R1 or IGF-IR confers proliferative advantage to VSMCs, mainly in response to TNF-a or IGF-II, which might be of significance in the early atherosclerotic process
Ilvesmäki et al., Mol Cell Endocrinol 1993 : Tumor necrosis factor-alpha and interferon-gamma inhibit insulin-like growth factor II gene expression in human fetal adrenal cell cultures
Noble et al., J Clin Invest 1993 (Fibrosis...) : Furthermore, IGF-1 induction was dependent on endogenous TNF alpha production since IGF-1 protein synthesis was inhibited in the presence of anti-TNF alpha antiserum