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IL12B — TNF

Text-mined interactions from Literome

Wang et al., J Clin Invest 1999 (Mycobacterium Infections) : Our data reveal that macrophages are a significant source of type 1 cytokines during mycobacterial infection and that both IL-12 and intracellular pathogens are required for the release of IFN-gamma but not TNF-alpha
Butler et al., Eur J Immunol 1999 (Arthritis) : When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro, anti-TNF diminished IL-12 production, but anti-IL-12 had no effect on TNF production
Takayama et al., J Invest Dermatol 1999 : Both GM-CSF and TNF-alpha induced the migration of human Langerhans cells in vitro, whereas IL-1beta, IL-2, IL-10, IL-12 , and IFN-gamma had no effect on Langerhans cell migration
Kitagawa et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : To investigate the roles of tumor necrosis factor alpha(TNFalpha) and the CD40-CD154 interaction in interleukin-12 (IL-12) production by rheumatoid synovial cells ( SC ) ... TNFalpha restored LPS stimulated IL-12 production that had been inhibited by rolipram
Hartung et al., Clin Pharmacol Ther 1999 : IL-12 added in vitro to lipopolysaccharide stimulated blood of filgrastim treated donors restored IFN-gamma and TNF-alpha release, suggesting that the anti-inflammatory effect of granulocyte colony stimulating factor is exercised through IL-12 suppression
Becher et al., J Neuroimmunol 2000 : IL-12 secretion by microglia is significantly reduced by TNF and IFN-gamma antagonists showing that the IL-12 production is subject to regulation by auto- and paracrine stimuli
Ma et al., J Immunol 2000 : IL-10 is not responsible for the TNF-alpha mediated inhibition of IL-12
Xing et al., J Leukoc Biol 2000 : In this study, we examined the role of IL-12 in macrophage TNF-alpha and nitric oxide ( NO ) release by using an in vitro model of intracellular infection ... However, IL-12 and mycobacteria together enhanced TNF-alpha and NO release synergistically ... Because IL-12 and mycobacteria also released IFN-gamma from macrophages synergistically, and exogenous IFN-gamma with mycobacteria enhanced TNF-alpha and NO release synergistically, we examined the role of endogenous IFN-gamma in IL-12/mycobacteria stimulated macrophage activation
Walter et al., J Exp Med 2001 (Asthma...) : Initial comparisons indicated that tumor necrosis factor alpha induction of epithelial intercellular adhesion molecule 1 required sequential induction of interleukin (IL)-12 ( p70 ) and interferon gamma, and unexpectedly localized IL-12 production to airway epithelial cells
Yanagawa et al., J Leukoc Biol 2002 : These findings suggest that TNF-alpha induced ERK activation negatively controls maturation and IL-12 production in murine DC
Obermeier et al., Eur J Immunol 2002 (Acute Disease...) : Colonic expression of IFN-gamma and TNF was elevated ( 200- and 150-fold, respectively ) and IFN-gamma and IL-12 secretion from lymph node cells was increased 5,000- and 8-fold, respectively, compared to GpG-ODN treated controls
Wilkin et al., Eur J Immunol 2002 : We observed that ATPgammaS potentiated the IL-12p40 release induced by TNF-alpha , but also by lipopolysaccharides (LPS) and soluble CD40 ligand ( sCD40L )
Drechsler et al., J Leukoc Biol 2002 : Inhibition of IL-12 by FcgammaR cross linking was not mediated by TNF-alpha , as the presence of an anti-TNF-alpha Ab could not restore the reduced IL-12 production
Kitaura et al., J Immunol 2002 : In contrast, IL-12 induced FasL transcription to lead to FasL expression on the surfaces of nonadherent bone marrow cells, whereas TNF-alpha could not induce FasL on the cells
Al-Mohanna et al., J Leukoc Biol 2002 : IL-12 dependent nuclear factor-kappaB activation leads to de novo synthesis and release of IL-8 and TNF-alpha in human neutrophils ... In addition IL-12 induces the de novo synthesis and production of IL-8 and tumor necrosis factor alpha (TNF-alpha) in a calcium- and ROM dependent manner
Zenclussen et al., Am J Reprod Immunol 2002 (Abortion, Spontaneous) : We further investigated the effect of recombinant human ( rh ) IL-12 on the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha in peripheral leukocytes ex vivo
Colpaert et al., Eur Cytokine Netw 2002 (Crohn Disease) : However, no effect of anti-IL-12 or anti-IFN-gamma on production of TNF , a cytokine with an important pathogenic role in Crohn 's disease, could be found
Yu et al., J Immunol 2003 (HIV Infections) : TNF-alpha and RANKL cooperated with CD40L via differing mechanisms, i.e., TNF-alpha enhanced IL-12 production, whereas RANKL enhanced survival of CD40L stimulated DCs
Gately et al., Cell Immunol 1992 : However, IL-12- and IL-2 induced LAK cell activation could be partially inhibited by anti-human TNF-alpha
Perussia et al., J Immunol 1992 : This inhibitory effect is, at least in part, indirect, and depends on IL-12 induced production of TNF
Naume et al., J Immunol 1992 : Thus, IL-12 can directly influence NK cell activities in purified CD56+ cells, and endogenously produced TNF-alpha is involved in mediating the effects of both IL-12 and IL-7
Fonseca et al., Vaccine 2004 (Granuloma...) : In an attempt to determine the role of IFN-gamma and TNF-alpha in IL-12 induced immunity, IFN-gamma and TNFR-p55 knockout mice were immunized with rSm14/IL-12 and no protection was achieved
Boelen et al., Horm Metab Res 2004 (Starvation) : IL-12 is involved in regulation of IFNgamma and TNFalpha
Schneider et al., J Immunol 2004 : IL-12 plus IL-18 rendered NK cells cytotoxic against Fas transfected target cells and promoted their production of IFN-gamma and TNF-alpha , which are both essential for sensitizing histamine producing cells to the Fas death pathway
Ebert et al., Clin Exp Immunol 2004 : Furthermore, IL-12 augmented IL-15 stimulated release of serine esterases as well as expression of perforin and FL by IELs, but not TNF-alpha
Zhu et al., J Biol Chem 2005 (Inflammation) : The ERK signaling pathway is not involved in TNF-alpha and nitric oxide production, but, interestingly, negatively regulates the expression of IL-6 and IL-12
Sato et al., Eur J Immunol 2005 (Shwartzman Phenomenon) : The neutralization of either IL-12 induced IFN-gamma or LPS induced TNF-alpha improved the survival of middle aged ( 25-week-old ) mice
Pedersen et al., Scand J Immunol 2005 (Breast Neoplasms) : Polyriboinosinic polyribocytidylic acid ( Poly I:C ) + tumour necrosis factor-alpha (TNF-alpha) induced significant IL-12 p70 secretion, which was increased after addition of a decoy IL-10 receptor
Agrawal et al., Int Immunol 2005 : MUC1 expression on activated T cells was increased in the presence of IL-12 but was not affected by IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-13 or TNF-alpha
Zakharova et al., J Immunol 2005 (Listeriosis) : TNFR1 was established as the main receptor involved in IL-12p40 regulation, because IL-12p40 levels were not affected by TNF-alpha in TNFR1 ( -/- ) -derived macrophages
Roggen et al., Toxicol Lett 2006 (Hypersensitivity) : PGE ( 2 ) is synergistic with IL-1beta and TNF-alpha in the induction of functional and phenotypic maturation of DC and induce IL12 p40 production
Yang et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System...) : The enhancement of IL-12 levels by inhibition of PI 3-K and ERK 1/2 was not reversed by neutralization of TNF-alpha or addition of rhTNF-alpha, suggesting that the negative regulation of IL-12 is not mediated by concomitant TNF-alpha suppression
Zeuthen et al., Clinical and vaccine immunology : CVI 2006 : Interestingly, we found that when weakly IL-12- and TNF-alpha inducing LAB and strong IL-12- and TNF-alpha inducing LAB were mixed, the weakly IL-12- and TNF-alpha inducing LAB efficiently inhibited otherwise strong IL-12- and TNF-alpha inducing LAB, yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria, they synergistically induced IL-12 and TNF-alpha
Shan et al., Cell Mol Immunol 2006 (Carcinoma...) : IL-23 also promoted the production of Th1 cytokines such as IFN-gamma, IL-12 and TNF-alpha
Hao et al., Cancer Immunol Immunother 2006 (Neoplasms) : IL-23 can enhance the proliferation of memory T cells and the production of IFN-gamma, IL-12 and TNF-alpha from activated T cells
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12 , TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Husted et al., Inflamm Res 2006 (Reperfusion Injury) : Finally, isolated Kupffer cells produced TNFalpha in response to IL-23 , but not IL-12, suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion ... Finally, isolated Kupffer cells produced TNFalpha in response to IL-23, but not IL-12 , suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion
Watkins et al., J Immunol 2007 (Carcinoma, Lewis Lung...) : Analysis of tumor infiltrating macrophages and distal TAMs revealed that IL-12 , both in vivo and in vitro, induced a rapid ( < 90 min ) reduction of tumor supportive macrophage activities ( IL-10, MCP-1, migration inhibitory factor, and TGFbeta production ) and a concomitant increase in proinflammatory and proimmunogenic activities ( TNF-alpha , IL-15, and IL-18 production )
Bastos et al., J Interferon Cytokine Res 2007 : Here, we investigated the role of IL-12/IL-18 on nitric oxide ( NO ) and tumor necrosis factor-alpha (TNF-alpha) production by CD11b ( + ) adherent peritoneal cells, focusing on the involvement of endogenously produced IFN-gamma
Liu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : To explore the source of the p19 subunit of interleukin-23 (IL-23) in joints with rheumatoid arthritis ( RA ), the effects of IL-1beta and tumour necrosis factor (TNF)-alpha on IL-23 gene expression in RA fibroblast-like synoviocytes and the effect of IL-23 on proinflammatory cytokines
Ghosh et al., Int Immunopharmacol 2007 : TLR4-TLR7/8 combinations synergistically up-regulated IFN-gamma and IL-12 , enhanced IFN-alpha and also moderately induced TNF-alpha
Kageyama et al., Rheumatol Int 2007 (Arthritis, Gouty...) : TNF-alpha induced MIP-3alpha but not IL-23 production in cultured synovial cells from RA patients
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R , IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha , IL-2, and IL-10 secretion
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : These data indicate that CpG-ODN protects animals against lethal C. albicans challenge via a pathway that involves the TNF-alpha dependent induction of IL-12
Ochoa-Repáraz et al., Infect Immun 2007 (Q Fever...) : Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice, and immunocompetent macrophages showed robust tumor necrosis factor alpha, IFN-gamma, and granulocyte-macrophage colony stimulating factor ( GM-CSF ) but no interleukin-12 (IL-12) responses
Xu et al., Int J Tuberc Lung Dis 2008 : Our study demonstrated that after stimulation of alveolar macrophages by Mce4E protein for 48 h, the expression of TNF-alpha was induced , with an enhanced IL-6 mRNA level ( P < 0.05 ) and no changes in IL-12 expression in the macrophages
Enríquez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : TNF-alpha stimulated secretion of IL-12p40 was significantly increased by 30 min ; GM-CSF, MCP-1, IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Huang et al., Infect Immun 2009 : YGPs stimulated secretion of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) in wild-type murine bone marrow derived myeloid dendritic cells ( BMDCs ) but did not stimulate interleukin-12p70 (IL-12p70) production
Chaung et al., Vet Immunol Immunopathol 2009 : Zymosan enhanced dectin-1/TLR2/TLR4 expression and TNF-alpha/IL-10 production in all of three types of cell, whereas p-beta-glucan increased dectin-1/TLR4 and TNF-alpha/IL-12 production in AMs but inhibited IL-10 in mDCs
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF, TNF-alpha , and surface CD40L
Bluth et al., International journal of medical sciences 2009 (Hepatitis, Autoimmune) : In contrast, before treatment, IL-12 and TNFalpha were not detected in serum ; however after treatment the levels of IL-12 and TNFalpha dramatically increased
Yoshimatsu et al., Bone 2009 : IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell independent mechanism in vivo
Fukuda et al., Int J Oncol 2010 (Carcinoma, Squamous Cell...) : IL-23 , which constitutively expressed in oral cancer, was enhanced by TNF-alpha and IL-23
Negishi et al., Am J Reprod Immunol 2011 : ( ii ) TNF-a was also induced by LPS but was not affected by the presence of IL-2 and IL-12
Feng et al., J Parasitol 2010 : All tachyzoite and antigen preparations at high doses stimulated high levels of interleukin (IL) -12 , interferon (IFN) -gamma, and tumor necrosis factor (TNF) -alpha, except for heat killed tachyzoites and sNcAg, which induced moderate level of IL-12 and very low levels of IFN-gamma and TNF-alpha
Zhang et al., Cell Physiol Biochem 2010 : The results showed that TNF induced up to 2.7-fold increase in IL-4, but not IL-12 release from P815 cells, and PAR-2 antagonist peptide FSLLRY-NH ( 2 ) and PAR-4 antagonist peptide trans-cinnamoyl ( tc ) -YPGKF-NH ( 2 ) did not affect TNF induced IL-4 release
Ryan et al., Vet Immunol Immunopathol 2010 (Actinomycetales Infections...) : On day 12, TNF-a induction in monocyte derived macrophages and IL-12 p40 induction in BAL macrophages infected with R. equi was significantly higher in foals treated with PPVO than in controls
DeBenedette et al., J Immunother 2011 : In the presence of IL-12 , CTL differentiation toward lytic function is not accompanied by a reduction in the secretion of interferon-? and tumor necrosis factor-a
Fukuda et al., Mol Med Report 2010 : IL-23 and its receptor mRNAs and proteins were spontaneously expressed, and IL-23 was increased by TNF-a stimulation in the oral cancer cells
Kramp et al., Clin Exp Immunol 2011 (Tuberculosis) : TNF-a treatment induced a decrease in TNF-a, IL-12p40 and IL-10 mRNA levels in peritoneal cells following PPD stimulation while live M. tuberculosis caused an increase in TNF-a mRNA and a decrease in the IL-10 mRNA expression
Donini et al., Prostate 2012 (Prostatic Neoplasms) : LNCaP enhance IL-1ß, IL-23, IL-6, and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase unrelated mechanisms
Wu et al., DNA Cell Biol 2012 : Exposure to VPA significantly repressed the production of interleukin 12 (IL-12) , and tumor necrosis factor a by lipopolysaccharide (LPS) induced macrophage activation, in contrast, promoted IL-10 expression
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12) , and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Kim et al., J Immunol 2012 (Disease Models, Animal...) : PLC activation enhanced the bactericidal activity and hydrogen peroxide production of mouse neutrophils, and it also enhanced the production of IFN-? and IL-12 while inhibiting proseptic TNF-a and IL-1ß production in cecal ligation and puncture mice
Perez-Aso et al., Inflammation 2013 (Arthritis, Rheumatoid...) : Interestingly, TNF-a , but not CGS21680, dramatically inhibited IL-12 mRNA expression
Feriotti et al., PloS one 2013 (Disease Susceptibility...) : Importantly, both mannan and P. brasiliensis induced the production of IL-12 by B10.A macrophages, whereas TGF-ß, TNF-a and IL-6 were produced by A/J cells
Kitaura et al., Clin Dev Immunol 2013 (Arthritis, Rheumatoid...) : IL-12, IL-18, and IFN- ? induce apoptosis in bone marrow cells treated with TNF- a ??in vitro, and osteoclastogenesis is inhibited by the interactions of TNF- a -induced Fas and Fas ligand induced by IL-12 , IL-18, and IFN- ?
Salkowski et al., J Immunol 1995 : In the spleen, IL-6 and TNF-alpha were induced by 30 min after LPS challenge, while increases in IL-10 and IL-12 ( p40 ) were delayed in onset
Cesano et al., Cancer Immunol Immunother 1995 : CsA did not impair the ability of TALL-104 and LAK cells to produce interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, and granulocyte/macrophage-colony-stimulatory factor ( GM-CSF ) in response to IL-2, IL-12 , or tumor targets
Ogata et al., Br J Haematol 1995 (Myelodysplastic Syndromes) : The effects of interleukin 12 (IL-12) on natural killer ( NK ) cell cytotoxicity and on the production of interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) were examined in 15 patients with myelodysplastic syndromes (MDS), which are well known to have immunologic defects, and in 11 normal subjects
Orange et al., J Exp Med 1995 (Lymphocytic Choriomeningitis) : Northern blot and in situ hybridization analyses demonstrated that IL-12 induced TNF-alpha expression and that LCMV infection synergized with IL-12 for induction of this factor
Jewett et al., Cell Immunol 1994 : The 55-kDa TNF receptor ( TNF-R p55 ), however, was not affected by IL-12 , but in the presence of anti-IFN-gamma antibody, its expression was enhanced
Aste-Amezaga et al., Cell Immunol 1994 : It was found that IL-12 induces mRNA accumulation and production of GM-CSF and TNF-alpha from both T and NK cells and, as tested on NK cells only, induces M-CSF mRNA accumulation
Naume et al., Cytokine 1993 : Furthermore, IL-4 induced a slight increase in the IL-12 stimulated TNF production
Wu et al., J Immunol 1993 : IL-12 also induces neonatal CD4 T cells to produce lymphotoxin but not IL-2, TNF-alpha , or IL-4
Daftarian et al., J Immunol 1996 : IL-12 and/or IL-6 can induce the expression of IL-10 by PHA stimulated T cells, whereas TNF-alpha induces IL-10 production by monocytes
Xiao et al., J Hematother 1996 : To understand the possible mechanisms for this suppression, ELISA assays were used to detect the release of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha , which could potentially have been induced by IL-12 from CD34 cells ... The results suggest that the suppressive effects of IL-12 on retroviral gene transduction are, at least in part, mediated by IL-12 induction of the release of TNF-alpha
Becher et al., J Clin Invest 1996 : IL-12 production is preceded by TNF-alpha production and is inhibited by recombinant soluble human TNF receptor ( II ) -IgG1 fusion protein ( shu-TNF-R )
Cantorna et al., J Infect Dis 1996 (Arthritis, Infectious...) : Earlier and stronger interleukin (IL)-12 , interferon-gamma (IFN)-gamma, and tumor necrosis factor responses were found in Borrelia burgdorferi infected, vitamin A-deficient mice compared with controls
Noguchi et al., Proc Natl Acad Sci U S A 1996 (Skin Neoplasms) : Interferon gamma, IL-10, and tumor necrosis factor could be induced throughout the treatment period by IL-12 , indicating that repeated injections of IL-12 do not induce a state of tachyphylaxis
Heinzel et al., J Immunol 1996 (Endotoxemia) : Pretreatment of IFN-gamma 0/0 mice with recombinant mouse IFN-gamma ( rIFN-gamma ) enhanced circulating TNF-alpha by as much as sixfold, but serum IL-12 p40 and IL-12 p70 responses increased by only twofold or less
Ueta et al., Eur J Immunol 1996 : Furthermore, IL-12 up-regulated TNF receptors on gammadelta T cells in vitro : TNF-alpha binding to its receptor induced CD25 expression on the gammadelta T cells in an autocrine or paracrine fashion, or perhaps both
Enk et al., Photochem Photobiol 1996 : Because IL-12 induces production of TNF-alpha by certain cells of the immune system, we sought to determine whether UVB is an inducer of IL-12 gene expression in epidermal cells
Kornelisse et al., Infect Immun 1997 (Meningitis, Bacterial) : The production of IFN-gamma is induced by IL-12 with tumor necrosis factor alpha (TNF-alpha) as a costimulator and inhibited by IL-10
Yin et al., Arthritis Rheum 1997 (Arthritis, Reactive...) : Exogenous IL-12 clearly enhanced IFN gamma and TNF alpha secretion
Sacco et al., Blood 1997 : The IL-12 predose also inhibited IL-12 induced IFN-gamma levels, but did not modify IL-12 induced CS, TNF or sTNFR-P75
Berger et al., Eur J Immunol 1997 : We found that exogenously added TNF-alpha caused a profound inhibition of monocytic IL-12 secretion in the absence of IC, again mediated via the induction of IL-10 and PG
Grewe et al., J Immunol 1998 : The expression of both IL-12 protein and mRNAs for the p35 and p40 IL-12 subunits was strongly induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage CSF and was also moderately induced by TNF-alpha and IL-1alpha
Suen et al., Vaccine 1998 : Furthermore, we have studied the effects of IL-12 and IL-15 on induction of IFN-gamma and TNF-alpha production, NK, and LAK activities in CB and APB ... The impaired ability of CB to produce IL-12 and IL-15 in response to stimulation may contribute to the decrease in IFN-gamma, TNF-alpha production, NK and LAK activities
Fulton et al., J Infect Dis 1998 : Regulation of interleukin (IL)-12 production by coexpression of tumor necrosis factor (TNF)-alpha , IL-10, and transforming growth factor ( TGF ) -beta in human monocytes infected with Mycobacterium tuberculosis H37Ra was analyzed ... TNF-alpha protein expression occurred earlier than IL-12 p40 protein but was not required for IL-12 induction
Hodge-Dufour et al., Proc Natl Acad Sci U S A 1998 (Inflammation) : To determine whether TNF inhibition of IFN-gamma induced IL-12 production contributed to the resolution of an inflammatory response in vivo, the response of TNF+/+ and TNF-/- mice injected with Corynebacterium parvum were compared
Becher et al., J Immunol 1999 : Based on previous work that suggests that the production of IL-12 by activated human central nervous system derived microglia is regulated by autocrine TNF-alpha , we wanted to determine whether inhibition of TNF could induce a reduction of Th1 responses by its impact on systemic APCs