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TNF — TPX2

Text-mined interactions from Literome

Derudder et al., J Biol Chem 2003 : RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation : critical roles for p100 ... Moreover, we show that RelB, p50, and p100 can associate in the same complex and that TNF-alpha but not LTbeta signaling increases the association of p100 with RelB/p50 dimers in the nucleus, leading to the specific inhibition of RelB DNA binding
Wang et al., J Biol Chem 2007 (Thrombosis) : By electrophoretic mobility shift assay analyses, TNF-alpha and lipopolysaccharide induce strong p65/p50 and p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes
Yao et al., J Clin Invest 2009 (Bone Resorption) : TRAF3 siRNA prevented TNF induced NF-kappaB p100 accumulation and inhibition of osteoclastogenesis
Tanaka et al., J Clin Invest 2009 : TNF-alpha induced a sustained accumulation of p100 in osteoclast precursors, and TNF-alpha induced osteoclast formation was markedly increased in Nfkb2-/- mice
Madge et al., J Biol Chem 2010 : TNF did not inhibit the NC NF-?B pathway activation as LIGHT induced p100 processing to p52 was intact ; however, TNF either alone or together with LIGHT up-regulated p100 and RelB expression and induced the nuclear localization of p100-RelB complexes
Jahnke et al., FEBS Lett 1994 (Melanoma) : Synergistic activation of intercellular adhesion molecule 1 ( ICAM-1 ) by TNF-alpha and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha ( p91 ) that can be activated by both IFN-gamma and IFN-alpha
Jahnke et al., Immunobiology 1995 (Melanoma) : Using electrophoretic mobility shift assays and specific antibodies we observed that the NF-kappa B like sequence at -187 bound both p65/p50 and p65/c-Rel in the presence of TNF-alpha , while the interferon responsive region at -75 bound Stat1 alpha ( p91 )
de Wit et al., Leukemia 1998 (Inflammation) : The results demonstrate that LPS, IL-1beta, and TNF-alpha induce p100 expression at mRNA and protein level while IFN-gamma, IL-3 and IL-4/IL-10 have no effect