Gene interactions and pathways from curated databases and text-mining

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EGF — HMGCR

Text-mined interactions from Literome

Asslan et al., Biochem Biophys Res Commun 1999 (Adenocarcinoma...) : Epidermal growth factor (EGF) increased the HMG-CoA reductase activity, protein, and mRNA levels only in ErbB-2 expressing cells ( SKBR-3 and MCF-7 ) but not in MDA-MB-468 cells that do not express ErbB-2 even though their EGF receptor was efficiently phosphorylated
Harris et al., J Invest Dermatol 2000 : Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes
Singh-asa et al., Int J Biochem 1985 : EGF increases the activity of the rate limiting enzyme in cholesterol biosynthesis, HMG CoA reductase