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CXCL12 — PTPN11
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CXCR4-mediated signaling events:
G beta/gamma complex (GNB1-GNG2)
→
SDF1/CXCR4/SHP1-2 complex (CXCL12-CXCR4-PTPN6_PTPN11)
(modification, activates)
Vila-Coro et al., FASEB J 1999, Chernock et al., Blood 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/SHP1-2 complex (CXCL12-CXCR4-PTPN6_PTPN11)
→
SDF1/CXCR4 complex (CXCL12-CXCR4)
(modification, collaborate)
Vila-Coro et al., FASEB J 1999, Chernock et al., Blood 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/SHP1-2 complex (CXCL12-CXCR4-PTPN6_PTPN11)
→
SHP1-2 (PTPN6/PTPN11)
(modification, collaborate)
Vila-Coro et al., FASEB J 1999, Chernock et al., Blood 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4 complex (CXCL12-CXCR4)
→
SHP1-2 (PTPN6/PTPN11)
(modification, collaborate)
Vila-Coro et al., FASEB J 1999, Chernock et al., Blood 2001
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Fernandis et al., Oncogene 2004
(Breast Neoplasms...) :
CXCL12 induced the activation of PI 3-kinase, and
increased its association with Cbl and
SHP2
Mamik et al., PloS one 2012
:
Src homology-2 domain containing protein tyrosine phosphatase (
SHP) 2 and p38
regulate the expression of chemokine
CXCL8 in human astrocytes ... Thus, our findings suggest an important
role for
SHP2 in
CXCL8 expression in astrocytes during inflammation, as SHP2, directly or indirectly, modulates p38 and ERK MAPK in the signaling cascade leading to CXCL8 production