Gene interactions and pathways from curated databases and text-mining

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FABP4 — PPARA

Pathways - manually collected, often from reviews:

  • WikiPathways PPAR signaling pathway: Complex of RXRA-PPARA-RXRG-RXRB → ANGPTL4/ADIPOQ/PLIN1/MMP1/MMP1/SORBS1/FABP4 (mim-transcription-translation)

Text-mined interactions from Literome

Mochizuki et al., Arch Biochem Biophys 2001 : These results suggest that the transcriptions of CRBPII, L-FABP , and the other PPAR dependent genes in the small intestine may be coordinately regulated by the disproportional expression of PPARalpha and PPARdelta
Fujishiro et al., Mol Cell Biochem 2002 : Analysis of tissue-specific and PPARalpha dependent induction of FABP gene expression in the mouse liver by an in vivo DNA electroporation method
Schachtrup et al., Biochem J 2004 (Carcinoma, Hepatocellular...) : All PPAR/RXR heterodimers transactivate L-FABP-PPRE , best are combinations of PPARalpha with RXRalpha or RXRgamma ... In contrast, PPARalpha heterodimers do not transactivate A-FABP-PPRE , best combinations are of PPARgamma1 with RXRalpha and RXRgamma, and of PPARgamma2 with all RXR subtypes
Boiteux et al., Int J Cancer 2009 (Carcinoma, Transitional Cell...) : A-FABP , a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells
Goto et al., Journal of the American Heart Association 2013 : We investigated whether peroxisome proliferator activated receptor-? ( PPAR? ) induces expression of fatty acid binding protein 4 (FABP4) and fatty acid translocase (FAT)/CD36 in capillary endothelial cells ( ECs ) to promote FA transport into the heart