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FABP4 — PPARA
Pathways - manually collected, often from reviews:
-
WikiPathways PPAR signaling pathway:
Complex of RXRA-PPARA-RXRG-RXRB
→
ANGPTL4/ADIPOQ/PLIN1/MMP1/MMP1/SORBS1/FABP4
(mim-transcription-translation)
Text-mined interactions from Literome
Mochizuki et al., Arch Biochem Biophys 2001
:
These results suggest that the transcriptions of CRBPII,
L-FABP , and the other PPAR dependent genes in the small intestine may be coordinately
regulated by the disproportional expression of
PPARalpha and PPARdelta
Fujishiro et al., Mol Cell Biochem 2002
:
Analysis of tissue-specific and
PPARalpha dependent induction of
FABP gene expression in the mouse liver by an in vivo DNA electroporation method
Schachtrup et al., Biochem J 2004
(Carcinoma, Hepatocellular...) :
All
PPAR/RXR heterodimers
transactivate L-FABP-PPRE , best are combinations of PPARalpha with RXRalpha or RXRgamma ... In contrast,
PPARalpha heterodimers do not
transactivate A-FABP-PPRE , best combinations are of PPARgamma1 with RXRalpha and RXRgamma, and of PPARgamma2 with all RXR subtypes
Boiteux et al., Int J Cancer 2009
(Carcinoma, Transitional Cell...) :
A-FABP , a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially
regulated by
PPAR in urothelial cancer cells
Goto et al., Journal of the American Heart Association 2013
:
We investigated whether peroxisome proliferator activated receptor-? (
PPAR? )
induces expression of
fatty acid binding protein 4 (FABP4) and fatty acid translocase (FAT)/CD36 in capillary endothelial cells ( ECs ) to promote FA transport into the heart