Gene interactions and pathways from curated databases and text-mining

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IL4 — SP1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: SP1 → IL4 (increases, IL4 Activity)
    Evidence: In endothelial cells IL-4 acts to increase VCAM-1 mRNA stability and VCAM-1 gene transcription in a timeand dose-dependent manner via SP-1 transcription factor activation [99, 100].