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CIITA — TNF

Text-mined interactions from Literome

Rahat et al., Int Immunol 2001 : Increased binding of IFN regulating factor 1 mediates the synergistic induction of CIITA by IFN-gamma and tumor necrosis factor-alpha in human thyroid carcinoma cells ... The aim of this study was to find whether CIITA is synergistically induced by IFN-gamma and TNF-alpha in the human thyroid MRO-87-1 cell line, and to investigate the molecular mechanisms responsible for this synergism ... We have demonstrated that IFN-gamma and TNF-alpha synergistically induce HLA-DRalpha and CIITA mRNAs, but prolonged incubation resulted in the inhibition of CIITA mRNA accumulation
Kim et al., Diabetologia 2002 (Insulinoma...) : IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA ; nicotinamide reduced the expression of cytokine induced MHC class II expression on insulinoma cells through its effect on CIITA expression ; and the preventive effect of nicotimamide on Type I ( insulin dependent ) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis