Kramer et al., J Appl Physiol 2011
(Airway Remodeling...) :
Thus rapamycin reduced airway remodeling and AHR, demonstrating an important role for mTOR signaling in TGF-a-induced/EGF receptor mediated reactive airway disease
Xu et al., J Biol Chem 2012
:
Cycloheximide, a translation elongation inhibitor known to augment intracellular amino acid levels, prevented the effect of bafilomycin on amino acids levels and completely reversed its inhibition of EGF induced mTORC1 activation
Haslinger et al., Biol Reprod 2013
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Accordingly, a decrease in EGF stimulated phosphorylation of AKT ( Ser473 and Thr308 ) and its downstream target mTORC1 ( Ser2448 ) was noticed in AKT1 and AKT3 shRNAmir cell pools