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SETD2 — STAT3

Text-mined interactions from Literome

Xu et al., Oncogene 2005 (Neoplasms) : Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways ... Targeting Stat3 with a small-molecule inhibitor blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo
Niu et al., Zhongguo Dang Dai Er Ke Za Zhi 2007 (Kidney Neoplasms...) : Stat3 may regulate the expression of HIF-1 and VEGF, so it could be an effective target for inhibiting VEGF expression and angiogenesis of Wilms ' tumor
Wheeler et al., Oncogene 2010 (Carcinoma, Squamous Cell...) : These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-a , which contribute to cetuximab resistance in EGFRvIII expressing HNSCC tumors
Boreddy et al., PloS one 2011 (Neoplasm Invasiveness...) : STAT-3 over-expression or IL-6 treatment significantly induced HIF-1a and VEGF expression ; however, BITC substantially suppressed STAT-3 as well as STAT-3 induced HIF-1a and VEGF expression
Adachi et al., Oral Oncol 2012 (Carcinoma, Squamous Cell...) : STAT3 mediated HIF-1a expression was also reduced in response to Stattic treatment
Albasanz-Puig et al., Biochem Biophys Res Commun 2012 : STAT-1 suppresses HIF-1a expression, whereas STAT-3 positively regulates HIF-1a expression ... These results provide evidence that activated STAT-1 and STAT-3 regulate VEGF expression indirectly, by modulating HIF-1a activity
Nechemia-Arbely et al., Clin Exp Pharmacol Physiol 2013 : These in vivo studies suggest that, in response to renal hypoxic-stress, upregulation of HIF-1 and activation of STAT3 may be both reciprocal and cell type dependent
Pawlus et al., PloS one 2013 : Using siRNA or inhibitor, we previously reported that STAT3 or USF2 is specifically required for activation of endogenous HIF1 or HIF2 target genes