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ELANE — MUC16
Text-mined interactions from Literome
Shao et al., J Immunol 2005
:
Neutrophil elastase induces MUC5AC
mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha converting enzyme
Song et al., Korean J Intern Med 2005
:
Neutrophil elastase causes MUC5AC
mucin synthesis via EGF receptor, ERK and NF-kB pathways in A549 cells
Zheng et al., Free Radic Biol Med 2007
(Adenocarcinoma...) :
Neutrophil elastase (NE) , a potent neutrophil inflammatory mediator,
increases MUC5AC
mucin gene expression through undefined pathways involving reactive oxygen species
Nadziejko et al., Am J Respir Cell Mol Biol 1994
:
The purpose of this study was to examine the
effects of
mucus glycoprotein ( mucin ) , one of the most plentiful high molecular weight polyanions in the respiratory tracts, on
HLE activity ... Human airway
mucin and bovine submaxillary mucin at concentrations of 0.4 to 2.8 mg/ml both markedly
inhibited the elastolytic activity of 50 nM
HLE , with maximum inhibition approaching 90 %