Gene interactions and pathways from curated databases and text-mining

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HLA-A — TNF

Text-mined interactions from Literome

Zheng et al., J Immunol 2000 : Transduced Bcl-2 did not reduce TNF mediated NF-kappaB activation or constitutive expression of class I MHC molecules
Willemsen et al., J Immunol 2005 (Melanoma) : Human scFv-G8 ( POS ) T lymphocytes comprising the gamma + CD28 vs the gamma signaling element alone produced substantially more IL-2, TNF-alpha , and IFN-gamma in response to HLA-A1/MAGE-A1 ( POS ) melanoma cells
Doukas et al., J Immunol 1990 : TNF but not IL-1 also increases class I MHC Ag expression
Hinrichs et al., Mol Immunol 2009 : Stimulation with IFN-gamma and/or TNF-alpha led to an increase of HLA-A*3014L secretion to a detectable level and increased HLA-A*3001 expression up to 8-fold, but did not show any difference in the increase of mRNA levels between HLA-A*3014L and A*3001
Leszczynski et al., Am J Pathol 1990 : Finally, TNF alpha induced class I MHC expression was inhibited strongly by IL-1 alpha
Pfizenmaier et al., J Immunol 1987 (Neoplasms) : Tumor necrosis factor enhances HLA-A , B,C and HLA-DR gene expression in human tumor cells
Yoshioka et al., Liver 1989 : These findings suggest that IFN alpha, IFN gamma, and TNF alpha may play similar roles in enhancement of HLA-A , B, C expression of hepatocytes in hepatitis and hepatoma cells
Pober et al., Ciba Found Symp 1987 (Inflammation) : Coincident with morphological change, TNF and LT ( but not IL-1 alpha or IL-1 beta ) cause a marked increase in HLA-A , B mRNA and antigen expression
Stephens et al., J Autoimmun 1997 (Diabetes Mellitus, Type 1) : In the current study we have examined the effect of the same inhibitor of NF-kappaB on class I major histocompatibility complex ( MHC ) protein expression in NIT-1 cells and shown that inhibition of NF-kappaB activation decreased basal and TNF induced class I MHC levels