Gene interactions and pathways from curated databases and text-mining

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GSTP1 — MBD2

Text-mined interactions from Literome

Bakker et al., J Biol Chem 2002 (Carcinoma, Hepatocellular) : To test whether MBD2 might be responsible for the inhibition of GSTP1 transcription from hypermethylated GSTP1 promoters, siRNAs were used to reduce MBD2 polypeptide levels in Hep3B cells
Lin et al., Cancer Res 2003 (Breast Neoplasms) : We report here thathypermethylation of CpG dinucleotides at the 5 ' transcriptional regulatory region was sufficient to inhibit GSTP1 transcription in MCF-7 breast cancer cells and that repression of GSTP1 transcription was mediated in part by the methyl-CpG binding domain ( MBD ) protein MBD2