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MIF — RELA
Text-mined interactions from Literome
Lacey et al., Arthritis Rheum 2003
(Hyperplasia) :
Activation of
NF-kappa B was
induced by IL-1 beta, but not by
MIF
Onodera et al., Arthritis Rheum 2004
(Arthritis, Rheumatoid...) :
MIF enhanced AP-1 and
NF-kappaB binding activities in a dose dependent manner
Cao et al., Biol Reprod 2005
:
Stimulation of
macrophage migration inhibitory factor expression in endometrial stromal cells by interleukin 1, beta
involving the nuclear transcription factor
NFkappaB
Hagemann et al., J Immunol 2005
(Breast Neoplasms...) :
EMMPRIN and
MIF were up-regulated in cocultured tumor cells in a JNK- and
NF-kappaB dependent manner
Aeberli et al., FEBS Lett 2006
(MAP Kinase Signaling System) :
This is associated with increased expression of mitogen activated protein kinase ( MAPK ) phosphatase-1 ( MKP-1 ), concomitant decreased phosphorylation of p38 MAPK, but no
effect of
MIF on
nuclear factor kappaB (NF-kappaB)
Larsen et al., Cancer Lett 2008
(Breast Neoplasms) :
Inhibition of HIF-1alpha, HIF-2alpha,
NF-kappaB and C/EBPbeta using siRNA
had no effect on hypoxia induced
MIF secretion
Veillat et al., Fertil Steril 2009
(Endometriosis...) :
To investigate the
involvement of the
nuclear factor (NF)-kappaB in the interleukin (IL)-1 beta mediated
macrophage migration inhibitory factor ( MIF ) gene activation ... This study suggests the
involvement of the nuclear transcription factor
NF-kappaB in
MIF gene activation in ectopic endometrial cells in response to IL-1 beta and identifies a possible pathway of endometriosis associated inflammation and ectopic cell growth
Cho et al., Immunol Lett 2009
:
NF-kappaB inhibition
leads to increased synthesis and secretion of
MIF in human CD4+ T cells ... To examine the
effects of
nuclear factor kappa B (NF-kappaB) inhibition on the secretion of
macrophage migration inhibitory factor ( MIF ) in human CD4 ( + ) T cells ... These results indicate that pharmacological inhibition of
NF-kappaB causes the release of MIF through de novo synthesis of
MIF and the secretion of preformed MIF in CD4 ( + ) T cells through the production of reactive oxygen species