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IRF5 — TLR8
Text-mined interactions from Literome
Takaoka et al., Nature 2005
(Inflammation...) :
We also provide evidence that
IRF-5 interacts with and is
activated by MyD88 and TRAF6, and that
TLR activation results in the nuclear translocation of IRF-5 to activate cytokine gene transcription
Schoenemeyer et al., J Biol Chem 2005
:
Here we show that in contrast to IRF3 and IRF7,
IRF5 is not a target of the TLR3 signaling pathway but is
activated by TLR7 or
TLR8 signaling
Atzei et al., J Biol Chem 2010
:
We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses
TLR induced
activation of NF-?B and
interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses