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FYN — VAV1

Pathways - manually collected, often from reviews:

• BioCarta t cell receptor signaling pathway: FYN → Vav (VAV1) (modification, activates)
• Reactome Reaction: FYN → VAV1 (indirect_complex) Hehner et al., J Biol Chem 2000, Tybulewicz et al., Immunol Rev 2003, Tybulewicz et al., Curr Opin Immunol 2005, Schneider et al., Biochem Biophys Res Commun 2008*, Michel et al., J Biol Chem 1998
• Reactome Reaction: FYN → VAV1 (reaction) Hehner et al., J Biol Chem 2000, Tybulewicz et al., Immunol Rev 2003, Alai et al., J Biol Chem 1992, Tybulewicz et al., Curr Opin Immunol 2005, Schneider et al., Biochem Biophys Res Commun 2008*, Timokhina et al., EMBO J 1998*, Michel et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VAV1 — FYN (direct interaction, two hybrid) Tartare-Deckert et al., J Biol Chem 2001*
• IRef Biogrid Interaction: VAV1 — FYN (physical association, affinity chromatography technology) Michel et al., J Biol Chem 1998
• IRef Ophid Interaction: FYN — VAV1 (aggregation, confirmational text mining) Michel et al., J Biol Chem 1998
• IRef Ophid Interaction: FYN — VAV1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Huang et al., Proc Natl Acad Sci U S A 2000 : Finally, study of T cells from a Fyn-deficient TCR transgenic mouse also showed that Fyn was required for tyrosine phosphorylation and activation of Vav induced by both antagonist and agonist peptides
Michel et al., J Biol Chem 1998 : Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen presenting cells