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CHUK — CXCL1
Text-mined interactions from Literome
Devalaraja et al., Cancer Res 1999
(Melanoma) :
Elevated constitutive
IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells
lead to increased basal
MGSA/GRO-alpha transcription
Yang et al., Cancer Res 2001
(Melanoma) :
Moreover, recombinant
CXCL1 can directly
induce IKK activity in normal human epidermal melanocytes in a concentration dependent manner after up-modulation of CXCL1 protein expression, whereas inhibition of IKKbeta activity results in down-modulation of CXCL1 protein expression
Yang et al., Clin Cancer Res 2006
(Melanoma) :
Inhibition of constitutive
IKK activity by BMS-345541
resulted in the reduction of NF-kappaB activity,
CXCL1 chemokine secretion by cultured melanoma cells and melanoma cell survival in vitro and in vivo
Edwards et al., Mol Immunol 2007
:
Focusing on CXCL8, both rhinovirus infection and dsRNA treatment
required IkappaB kinase-beta for induction of
CXCL8