◀ Back to NFKB1
BIRC3 — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
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IRef Innatedb Interaction:
NFKB1
—
BIRC3
(unknown, -)
Hoberg et al., Mol Cell 2004
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IRef Innatedb Interaction:
NFKB1
—
BIRC3
(unknown, -)
Croxton et al., Cancer Res 2006*
Text-mined interactions from Literome
Erl et al., Circ Res 1999
:
Transfer of IkappaBalpha reduced human IAP-1 mRNA levels, which suggested that
IAP-1 is transcriptionally
regulated by
NF-kappaB
Vega et al., Adv Anat Pathol 2001
(Lymphoma, B-Cell, Marginal Zone...) :
Recent work suggests that
API2-MALT1 and BCL-10-MALT1 may
activate NF-kB and a common downstream signaling pathway
Schoemaker et al., J Hepatol 2002
(Hepatitis) :
cIAP2 is induced by cytokines in an
NF-kappaB dependent manner and overexpression of cIAP2 inhibits apoptosis
Uzzo et al., Clin Cancer Res 2002
(Prostatic Neoplasms) :
In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of
nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells,
reduce expression of NF-kappa B-controlled antiapoptotic protein
c-IAP2 , and activate c-Jun NH ( 2 ) -terminal kinases
Wen et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Consistent with this, we found that TL1A significantly increased the production of
c-IAP2 , a known NF-kappaB dependent anti-apoptotic protein, and that the
NF-kappaB inhibitor or cycloheximide
prevented its synthesis
Wang et al., J Biol Chem 2003
(Colonic Neoplasms) :
Activation of
NF-kappa B contributes to
cIAP-2 induction ; however, the cellular mechanisms regulating cIAP-2 expression have not been entirely defined ... Moreover, overexpression of PKC delta induced
cIAP-2 promoter activity and increased
NF-kappa B transactivation , suggesting regulation of cIAP-2 expression by a PKC delta/NF-kappa B pathway
Nawata et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of MEKK1km also reduced
NF-kappaB activation, and
inhibited antiapoptotic c-IAP1 and
c-IAP2 mRNA expression in response to the genotoxin
Yanai et al., J Infect Dis 2003
(Stomach Neoplasms) :
Super-repressor IkappaBalpha or
NF-kappaB inhibitor
reduced c-IAP2 transactivation by H. pylori, and exogenous expression of c-IAP2 inhibited apoptosis seen with H. pylori
Hübinger et al., Exp Hematol 2004
(Lymphoma, Large B-Cell, Diffuse) :
Furthermore, we showed that CD30 regulated expression of cIAP1 and
cIAP2 was
mediated by
NFkappaB
Hosokawa et al., Int J Hematol 2004
(Lymphoma, B-Cell, Marginal Zone) :
BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation can be assumed to be able to contribute to antiapoptosis, probably through NF-kappaB mediated up-regulation of several apoptotic inhibitor genes
Ho et al., Blood 2005
(Lymphoma, B-Cell...) :
API2-MALT1 and exogenous MALT1
increased constitutive
NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Fan et al., Oncogene 2005
:
HGF/SF induced the expression of several known NF-kappaB target genes ( cIAP-1 ( cellular inhibitor of apoptosis-1 ),
cIAP-2 , and TRAF-2 ( TNF receptor associated factor-2 ) ) in an
NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
Hosokawa et al., Apoptosis 2005
(Lymphoma, B-Cell, Marginal Zone...) :
This stability of
API2-MALT1 may thus
result in inappropriate
nuclear factor (NF)-kappaB activation, thereby contributing to the pathogenesis of MALT lymphoma ... Furthermore, BCL10/MALT1- and
API2-MALT1 induced
NF-kappaB activation may contribute to anti-apoptotic action probably through NF-kappaB mediated upregulation of apoptotic inhibitor genes
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
Furthermore, BCL10 and
cIAP2-MALT1 synergistically
activate NF-kappaB
Zhou et al., Br J Haematol 2006
(Lymphoma, B-Cell, Marginal Zone...) :
t ( 11 ; 18 ) ( q21 ; q21 ) occurs specifically in mucosa associated lymphoid tissue ( MALT ) lymphoma and the translocation generates a functional
API2-MALT1 fusion product that
activates nuclear factor (NF)kappaB
Nakagawa et al., Leukemia 2006
(Lymphoma, B-Cell, Marginal Zone) :
We recently demonstrated that
API2-MALT1 can
induce transactivation of the API2 gene through
NF-kappaB activation, thus highlighting a positive feedback-loop mechanism of self-activation by upregulating its own expression in t ( 11 ; 18 ) MALT lymphomas
Hu et al., Cell cycle (Georgetown, Tex.) 2006
:
Furthermore,
cIAP2-MALT1 and Bcl10 synergistically
activate NF-kappaB
Jin et al., Biochem J 2006
:
cIAP2 ( cellular inhibitor of apoptosis protein 2 ) is
induced by
NF-kappaB ( nuclear factor kappaB ) when cells need to respond quickly to different apoptotic stimuli ... Cell cycle dependent G2/M-phase-specific
cIAP2 expression is
enhanced by
NF-kappaB activation, and selective down-regulation of cIAP2 causes cells blocked in mitosis with nocodazole to become susceptible to apoptosis, indicating that the G2/M-phase-specific expression of cIAP2 contributes to the survival of mitotically arrested cells
Noels et al., J Biol Chem 2007
(Lymphoma, B-Cell, Marginal Zone...) :
Finally, binding of TRAF2 to BIR1 contributed to
NF-kappaB activation by
API2.MALT1 , although additional mechanisms involving BIR1 mediated raft association are also important
Lucas et al., Oncogene 2007
:
A dual role for the API2 moiety in
API2-MALT1 dependent
NF-kappaB activation : heterotypic oligomerization and TRAF2 recruitment ... Thus, API2 moiety mediated heterotypic oligomerization and TRAF2 binding both contribute to maximal
API2-MALT1 dependent
NF-kappaB stimulation
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular
inhibitor of apoptosis protein-1 , cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Ricci et al., Cancer Cell 2007
:
TRAIL
induced expression of antiapoptotic Mcl-1 and
cIAP2 through activation of
NF-kappaB
Kim et al., Cancer Lett 2008
:
In addition, treatment of PTX-2 down-regulated
NF-kappaB dependent gene expression, Cox-2,
IAP-1 , IAP-2 and XIAP, at the transcriptional and translational level
Varfolomeev et al., J Biol Chem 2008
:
Here we investigate the
role of c-IAP1 and
c-IAP2 in TNFalpha stimulated activation of
NF-kappaB ... Therefore, c-IAP1 and
c-IAP2 are
required for TNFalpha stimulated RIP1 ubiquitination and
NF-kappaB activation
Mahoney et al., Proc Natl Acad Sci U S A 2008
:
Both cIAP1 and
cIAP2 regulate TNFalpha mediated
NF-kappaB activation
Garrison et al., Oncogene 2009
:
Here, we investigated the role of TRAF2 in
c-IAP2/MALT1 induced
NF-kappaB activation ... Studies of
c-IAP2/MALT1 BIR1 mutant ( E47A/R48A ) that fails to
activate NF-kappaB showed loss of TRAF2 binding, but retention of TRAF6 binding, suggesting that interaction of c-IAP2/MALT1 with TRAF6 is insufficient for NF-kappaB induction ... Comparisons of the bioactivity of intact c-IAP2/MALT1 oncoprotein and BIR1 E47A/R48A c-IAP2/MALT1 mutant that can not bind TRAF2 in a lymphoid cell line provided evidence that TRAF2 interaction is critical for
c-IAP2/MALT1 mediated increases in the
NF-kappaB activity, increased expression of endogenous NF-kappaB target genes ( c-FLIP, TRAF1 ), and resistance to apoptosis
Momeny et al., Med Oncol 2010
:
Altogether, these issues show for the first time that ATO treatment could trammel cell growth and proliferation as well as induces apoptosis in NB-4 cells through induction of transcriptional levels of p73, TP53INP1, WNK2, lipocalin 2 as well as suppression of
NF-kappaB mediated induction of BCL-X ( L ),
cIAP2 , XIAP and survivin
Kwon et al., Biochem Biophys Res Commun 2010
(Neoplasms) :
Furthermore, expression of
NF-kappaB dependent genes, FLICE-inhibitory protein (FLIP),
inhibitor of apoptosis protein 1 ( c-IAP1 ), or X-linked inhibitor of apoptosis protein ( XIAP ) was reduced in TOPK depleted cells
Lu et al., J Neurochem 2010
(Ischemia...) :
The U0126 neuroprotection appears related to
NF-kappaB regulated transcriptional control of
c-IAP2
Fingas et al., Hepatology 2010
(Bile Duct Neoplasms...) :
Because cIAP-1 and
cIAP-2 also
promote nuclear factor kappa B (NF-kappaB) activation by the canonical pathway, the effect of JP1584 on this signaling pathway was examined
Chu et al., Proc Natl Acad Sci U S A 1997
:
When overexpressed in mammalian cells,
c-IAP2 activates
NF-kappaB and suppresses TNF cytotoxicity