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JUN — MAP3K4
Text-mined interactions from Literome
Sun et al., Oncol Rep 2011
:
We found that
MEKK1/MEKK4 as opposed to ASK1, are
responsible for TRAIL induced
c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation
Jin et al., Dev Biol 2013
:
Second,
MAP3K1 potentiated AP-2a expression and SRF and
AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation