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GRAP2 — IL2

Text-mined interactions from Literome

Asada et al., J Exp Med 1999 : Overexpression of wild-type Grf40 in Jurkat cells induced a significant increase of SLP-76 dependent interleukin (IL)-2 promoter and nuclear factor of activated T cell ( NF-AT ) activation upon T cell receptor ( TCR ) stimulation, whereas the COOH-terminal SH3 deleted Grf40 mutant lacked any recognizable increase in IL-2 promoter activity
Ling et al., Crit Care Med 2002 : In contrast to its effects on the janus kinase/STAT pathways, interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002 : This model probiotic also inhibits activation of the pro-apoptotic p38/mitogen activated protein kinase by tumor necrosis factor, interleukin-1alpha , or gamma-interferon
Pestka et al., Toxicology 2005 : Inhibition of p38 attenuated DON induced upregulation of IL-2 while all three MAPK inhibitors suppressed IL-8 upregulation
Rasheed et al., Arthritis Res Ther 2010 (Osteoarthritis) : Pomegranate extract inhibits the interleukin-1ß induced activation of MKK-3, p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes