Gene interactions and pathways from curated databases and text-mining

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CSF2 — IL8

Text-mined interactions from Literome

Yoshida et al., Int Immunol 1999 (Arthritis, Rheumatoid) : IL-6 and IL-8 induction but not GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG
Baqui et al., Oral Microbiol Immunol 1999 : Starting from 8 h of treatment and afterwards GM-CSF alone significantly increased IL-8 production in THP-1 cells ... GM-CSF ( 50 IU/ml ) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate ( PMA ), as compared to PMA treatment alone
Yamashita et al., Int Arch Allergy Immunol 1999 : Stimulation of eosinophils with GM-CSF + TNF-alpha induced significant increases in the synthesis and secretion of IL-8 which were associated with translocation of NF-kappaB p50 into the nucleus
Schäfer et al., Adv Perit Dial 1998 : Recombinant GM-CSF at concentrations found during CAPD peritonitis in vivo significantly increased the release of IL-8 and MCP-1 in a time- and dose dependent manner
Albanesi et al., J Invest Dermatol 2000 (Dermatitis, Allergic Contact...) : In addition, interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor , and interleukin-6, with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Kamthong et al., Biochem J 2000 : cAMP attenuates interleukin-1 stimulated macrophage colony stimulating factor ( M-CSF ) expression
Kim et al., J Immunol 2000 : Thus, HRV-16 induces epithelial expression of IL-8 and IL-6 by an NF-kappaB independent pathway, whereas induction of GM-CSF is at least partially dependent upon NF-kappaB activation
Abdelilah et al., J Immunol 2001 (Asthma) : The anti-IL-9 neutralizing Ab suppressed this effect, but had no effect on GM-CSF induced IL-8 release from PMNs. Taken together, these findings suggest a novel role for PMNs in allergic disease through the expression and activation of the IL-9R
Kamthong et al., Biochem J 2001 : Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes interleukin-1 induced human macrophage-colony-stimulating-factor expression
Ji et al., Acta Pharmacol Sin 2000 : The rhM-CSF promoted TNF-alpha, IL-6, and IL-8 inductions of monocytes and increased the percentages of CD11b, CD16, HLA I, and HLA II molecule expression on monocytes
Greiber et al., J Am Soc Nephrol 2002 : GM-CSF release by podocytes was also stimulated by lipopolysaccharide (LPS), interleukin-1 (IL-1), and phorbolester ( PMA )
Juvin et al., Arch Environ Health 2002 : Diesel exhaust particles induced a dose- and a time dependent increase in granulocyte macrophage-colony stimulating factor release and a transient inhibition of interleukin-8 release, but inert particles did not
Varney et al., In Vivo 2002 (Melanoma...) : In summary, we demonstrated that MCP-1 and M-CSF , critical for monocyte recruitment, activation and differentiation, differentially regulate IL-8 expression and may play an important role in monocyte/macrophage mediated tumor angiogenesis
Hamilton et al., Blood 1992 : II. Similarities and differences in the control of interleukin-1 induction of granulocyte-macrophage CSF and granulocyte-CSF production
Damle et al., Eur J Immunol 1992 : However, GMP-140 in conjunction with anti-T cell receptor alpha beta monoclonal antibodies augmented the production of granulocyte-macrophage colony stimulating factor GM-CSF and inhibited the production of interleukin-8 by Ag-primed T cells without influencing their tumor necrosis factor-alpha production
Culpitt et al., Thorax 2003 (Pulmonary Disease, Chronic Obstructive) : Resveratrol inhibited basal release of IL-8 in smokers and patients with COPD by 94 % and 88 % respectively, and inhibited GM-CSF release by 79 % and 76 % respectively
Cowburn et al., Eur J Immunol 2004 : In human neutrophils, TNF-alpha ( 200 U/ml ) induced rapid I kappa B-alpha degradation, NF-kappa B activation and IL-8 release ( 31.8+/-5.4 pg/10 ( 5 ) cells/2 h ), whereas GM-CSF ( 10 ng/ml ) stimulated an equivalent IL-8 release ( 26.5+/-4.5 pg/10 ( 5 ) cells/2 h ) without enhanced I kappa B-alpha degradation or NF-kappa B activation compared to control
Schröder et al., Cytokine 2005 : Neutrophils of a high purity and with a low degree of preactivation upregulate mRNA and de novo synthesize protein of both IL-1ra variants and IL-8 in response to granulocyte-macrophage colony stimulating factor and lipopolysaccharide
Matsuzaki et al., Cancer Sci 2006 : We have demonstrated previously that the Th1-cytokine conditioned bone marrow derived dendritic cell ( BMDC ) subset BMDC1 ( generated in the presence of granulocyte-macrophage colony stimulating factor [GM-CSF ] + interleukin [ IL]-3 + interferon [ IFN]-gamma+ IL-12 ) induces a much stronger type 1 immune response than BMDC0 ( GM-CSF + IL-3 )
Krinner et al., Mol Immunol 2007 : As a consequence, the antibody potently prevented both GM-CSF induced proliferation of TF-1 cells with a sub-nanomolar IC50 value and the production of the chemokine IL-8 by U937 cells
Leizer et al., Blood 1990 : Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor
Duan et al., Invest Ophthalmol Vis Sci 2007 (Keratitis, Herpetic) : GM-CSF stimulation of neutrophils induced their activation and the secretion of IL-8
Lambert et al., J Biol Chem 2007 (Respiratory Tract Infections) : The alpha, beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony stimulating factor , interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8
Wirotesangthong et al., Int Immunopharmacol 2008 : PE significantly decreased histamine and GM-CSF produced by an IgE mediated hypersensitive reaction, and inhibited eotaxin and IL-8 secretion in a TNF-alpha and IL-4 induced allergic reaction
Pazdrak et al., J Immunol 2008 : Importantly, we found that inhibition of ICAM-1 in activated eosinophils blocked GM-CSF induced expression of c-fos, c-myc, IL-8 , and TNF-alpha
Fuxman Bass et al., Mol Immunol 2008 : Granulocyte-macrophage colony stimulating factor increased IL-8 and IL-1beta secretion, and CD11b-upregulation induced by single stranded bacterial DNA
Essner et al., J Clin Lab Immunol 1990 : Differential effects of granulocyte-macrophage colony stimulating factor and macrophage colony stimulating factor on tumor necrosis factor and interleukin-1 production in human monocytes
Nozaki et al., J Invest Dermatol 1991 : Augmentation of granulocyte/macrophage colony stimulating factor expression by ultraviolet irradiation is mediated by interleukin 1 in Pam 212 keratinocytes
Wang et al., Int J Oncol 1995 : We report that all-trans retinoic acid ( tRA ) synergizes with LPS to enhance the production of granulocyte colony stimulating factor ( G-CSF ) in PMA treated cells, whereas the production of granulocyte-macrophage CSF, interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Szardien et al., Eur Heart J 2012 (Aortic Valve Stenosis...) : Regression of cardiac hypertrophy by granulocyte colony stimulating factor stimulated interleukin-1ß synthesis
Maeda et al., Vet Immunol Immunopathol 2013 (Dermatitis, Atopic) : Stimulation of CPEK cells with trypsin induced significant upregulation of the mRNA expression levels of tumor necrosis factor alpha ( TNF-a, P < 0.05 ), granulocyte-macrophage colony stimulating factor ( GM-CSF, P < 0.01 ), thymus and activation regulated chemokine ( TARC/CCL17, P < 0.01 ), and interleukin 8 ( IL-8/CXCL8, P < 0.01 )
Suzuki et al., J Perinatol 2013 : Serum levels of IL-6 and IL-8 had been already elevated in his cord blood, and serum levels of granulocyte-macrophage colony stimulating factor and IL-8 were significantly increased on the second day of life
Bradbury et al., Leukemia 1990 (Leukemia, Myeloid, Acute) : Endogenous interleukin-1 can regulate the autonomous growth of the blast cells of acute myeloblastic leukemia by inducing autocrine secretion of GM-CSF
Bot et al., Blood 1989 : Human multilineage colony stimulating factor ( multi-CSF ) /interleukin-3 (IL-3) induces colony formation from CFU-GEMM, BFU-E, and CFU-Eo when applied to in vitro cultures of highly enriched hematopoietic progenitor cells
Morrissey et al., Int Arch Allergy Appl Immunol 1989 (Chagas Disease) : Thus, we have found that exogenous GM-CSF augments the primary plaque forming response to sheep red blood cells and that this effect is due to upregulation of Ia antigen expression and interleukin 1 production by the macrophages
Motoyoshi et al., Exp Hematol 1989 : On the other hand, CSF-HU did not stimulate monocyte production of interleukin-1 and interferon
Kleinerman et al., Cancer Res 1988 (Neoplasms) : rGM-CSF in vitro also did not stimulate the tumoricidal function of normal monocytes or the secretion of interleukin-1 or tumor necrosis factor
Hachicha et al., J Exp Med 1995 (Gout...) : Both TNF-alpha and GM-CSF stimulated IL-8 production ; however, only TNF-alpha exerted a significant effect on MIP-1 alpha secretion in neutrophils ... IL-8 production induced by TNF-alpha and GM-CSF was synergistically enhanced in the presence of MSU or CPPD, whereas MIP-1 alpha secretion induced by TNF was completely inhibited in the presence of either MSU or CPPD
Murata et al., Neurol Med Chir (Tokyo) 1993 (Glioblastoma) : Exogenous GM-CSF stimulation had no effect on production of prostaglandin E2, interleukin-6 , or interleukin-8 by glioma cells
Arnold et al., Immunology 1994 (Respiratory Syncytial Virus Infections) : In addition, IL-3, G-CSF , IFN-gamma and TGF-beta 2, albeit at high concentrations, induced a low IL-8 release from non infected A549 cells
Takahashi et al., Blood 1993 : Effect of granulocyte-macrophage colony stimulating factor and interleukin-3 on interleukin-8 production by human neutrophils and monocytes ... Neutrophils produce IL-8 in response to GM-CSF but not to IL-3 ... In contrast, recombinant human granulocyte-CSF ( rhG-CSF ), at concentrations as high as 100 ng/mL, does not induce IL-8 in either cell type ... rhGM-CSF also induces IL-8 mRNA expression and IL-8 protein in the promonocytic cell line, U-937, whereas rhG-CSF does not ... Stimulation of neutrophils with rhGM-CSF resulted in an increase in cell associated IL-8 at 4 hours ... rhGM-CSF, and to a lesser degree rhIL-3, potently stimulated IL-8 secretion in cultures of heparinized whole blood, whereas rhG-CSF had no significant effect on IL-8 secretion ... Induction of IL-8 by GM-CSF may be physiologically important in enhancing the acute inflammatory response
Yokoshima et al., Nihon Jibiinkoka Gakkai Kaiho 1995 (Nose Neoplasms...) : Immunohistochemical study revealed the distribution of cytokines : GM-CSF was detected near the basement membrane of the tumor site, while IL-6 and IL-8 were detected in the superficial layer of nasal inverted papilloma
Pullyblank et al., Br J Cancer 1994 (Adenocarcinoma...) : Similarly, interleukin 2 receptor (IL-2R) expression ( percentage of positive cells ) was augmented in the presence of m17-1A ( 15 +/- 3 ), c17-1A ( 14 +/- 3 ) and cSF25 ( 25 +/- 3 ) when compared with no antibody ( 9 +/- 2 )
Rizzo et al., Exp Hematol 1994 : Regulation of interleukin-1 and tumor necrosis factor-alpha induced granulocyte-macrophage colony stimulating factor gene expression : potential involvement of arachidonic acid metabolism
Akahane et al., Exp Hematol 1993 : In the present study, we show that GM-CSF production in murine aorta derived vascular endothelial cells is regulated by two cytokines : interleukin-1 (IL-1), which induces the production of GM-CSF, and interferon gamma (IFN-gamma), which downregulates this production
McCain et al., Am J Respir Cell Mol Biol 1993 : Since both IL-8 and GM-CSF accumulate in sites of acute inflammation, PMN may induce IL-8 gene expression in response to GM-CSF and thereby amplify the acute inflammatory response by recruiting additional PMN into inflammatory sites
Mori et al., Rinsho Ketsueki 1993 (Eosinophilia...) : The activity of granulocyte-macrophage colony stimulating factor ( GM-CSF ) was detected in the supernatant of the cultured ATL cells, although interleukin-3, interleukin-5 , and GM-CSF activities were not detected in her serum
Hashimoto et al., Exp Hematol 1996 : Macrophage colony stimulating factor induces interleukin-8 production in human monocytes ... We have investigated the stimulatory effect of recombinant human macrophage colony stimulating factor ( rhM-CSF ) on interleukin-8 (IL-8) production by human peripheral blood monocytes
van Pelt et al., Blood 1996 : GM-CSF induced the release of interleukin-8 (IL-8) , but not of IL-6 or tumor necrosis factor alpha
Le Meur et al., Kidney Int 1996 (Uremia) : Since macrophage colony stimulating factor ( M-CSF ) is essential for the activation of several functions of monocytes and macrophages and their production of cytokines such as interleukin-1 , interleukin-6, and tumor necrosis factor alpha, we investigated its involvement in patients with CRF
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Ure et al., Br J Dermatol 1998 (Arthralgia...) : Granulocyte/macrophage colony stimulating factor increases wound-fluid interleukin 8 in normal subjects but does not accelerate wound healing ... However, GM-CSF increases IL-8 release, which is a potent chemotactic cytokine, indicating that GM-CSF might be of therapeutic value under conditions of impaired chemotaxis
Murphy et al., J Biol Chem 1998 (Alzheimer Disease) : Macrophage colony stimulating factor augments beta-amyloid induced interleukin-1, interleukin-6 , and nitric oxide production by microglial cells ... We showed that macrophage colony stimulating factor , a microglial activator found at increased levels in the central nervous system in AD, dramatically augments beta-amyloid peptide ( betaAP ) -induced microglial production of interleukin-1 , interleukin-6, and nitric oxide