◀ Back to IL8
CSF2 — IL8
Text-mined interactions from Literome
Yoshida et al., Int Immunol 1999
(Arthritis, Rheumatoid) :
IL-6 and
IL-8 induction but not
GM-CSF induction was inhibited in most of the RSF after pretreatment with AuTG
Baqui et al., Oral Microbiol Immunol 1999
:
Starting from 8 h of treatment and afterwards
GM-CSF alone significantly
increased IL-8 production in THP-1 cells ...
GM-CSF ( 50 IU/ml ) also significantly
increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate ( PMA ), as compared to PMA treatment alone
Yamashita et al., Int Arch Allergy Immunol 1999
:
Stimulation of eosinophils with
GM-CSF + TNF-alpha induced significant
increases in the synthesis and secretion of
IL-8 which were associated with translocation of NF-kappaB p50 into the nucleus
Schäfer et al., Adv Perit Dial 1998
:
Recombinant
GM-CSF at concentrations found during CAPD peritonitis in vivo significantly
increased the release of
IL-8 and MCP-1 in a time- and dose dependent manner
Albanesi et al., J Invest Dermatol 2000
(Dermatitis, Allergic Contact...) :
In addition,
interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage
colony stimulating factor , and interleukin-6, with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Kamthong et al., Biochem J 2000
:
cAMP attenuates
interleukin-1 stimulated macrophage
colony stimulating factor ( M-CSF ) expression
Kim et al., J Immunol 2000
:
Thus, HRV-16
induces epithelial expression of
IL-8 and IL-6 by an NF-kappaB independent pathway, whereas induction of
GM-CSF is at least partially dependent upon NF-kappaB activation
Abdelilah et al., J Immunol 2001
(Asthma) :
The anti-IL-9 neutralizing Ab suppressed this effect, but had no effect on
GM-CSF induced
IL-8 release from PMNs. Taken together, these findings suggest a novel role for PMNs in allergic disease through the expression and activation of the IL-9R
Kamthong et al., Biochem J 2001
:
Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes
interleukin-1 induced human
macrophage-colony-stimulating-factor expression
Ji et al., Acta Pharmacol Sin 2000
:
The
rhM-CSF promoted TNF-alpha, IL-6, and
IL-8 inductions of monocytes and increased the percentages of CD11b, CD16, HLA I, and HLA II molecule expression on monocytes
Greiber et al., J Am Soc Nephrol 2002
:
GM-CSF release by podocytes was also
stimulated by lipopolysaccharide (LPS),
interleukin-1 (IL-1), and phorbolester ( PMA )
Juvin et al., Arch Environ Health 2002
:
Diesel exhaust particles induced a dose- and a time dependent increase in granulocyte
macrophage-colony stimulating factor release and a transient
inhibition of
interleukin-8 release, but inert particles did not
Varney et al., In Vivo 2002
(Melanoma...) :
In summary, we demonstrated that MCP-1 and
M-CSF , critical for monocyte recruitment, activation and differentiation, differentially
regulate IL-8 expression and may play an important role in monocyte/macrophage mediated tumor angiogenesis
Hamilton et al., Blood 1992
:
II. Similarities and differences in the control of
interleukin-1 induction of granulocyte-macrophage
CSF and granulocyte-CSF production
Damle et al., Eur J Immunol 1992
:
However, GMP-140 in conjunction with anti-T cell receptor alpha beta monoclonal antibodies augmented the production of granulocyte-macrophage colony stimulating factor
GM-CSF and
inhibited the production of
interleukin-8 by Ag-primed T cells without influencing their tumor necrosis factor-alpha production
Culpitt et al., Thorax 2003
(Pulmonary Disease, Chronic Obstructive) :
Resveratrol inhibited basal release of
IL-8 in smokers and patients with COPD by 94 % and 88 % respectively, and
inhibited GM-CSF release by 79 % and 76 % respectively
Cowburn et al., Eur J Immunol 2004
:
In human neutrophils, TNF-alpha ( 200 U/ml ) induced rapid I kappa B-alpha degradation, NF-kappa B activation and IL-8 release ( 31.8+/-5.4 pg/10 ( 5 ) cells/2 h ), whereas
GM-CSF ( 10 ng/ml )
stimulated an equivalent
IL-8 release ( 26.5+/-4.5 pg/10 ( 5 ) cells/2 h ) without enhanced I kappa B-alpha degradation or NF-kappa B activation compared to control
Schröder et al., Cytokine 2005
:
Neutrophils of a high purity and with a low degree of preactivation upregulate mRNA and de novo synthesize protein of both IL-1ra variants and
IL-8 in
response to granulocyte-macrophage
colony stimulating factor and lipopolysaccharide
Matsuzaki et al., Cancer Sci 2006
:
We have demonstrated previously that the Th1-cytokine conditioned bone marrow derived dendritic cell ( BMDC ) subset BMDC1 ( generated in the presence of granulocyte-macrophage colony stimulating factor [GM-CSF ]
+ interleukin [ IL]-3 + interferon [ IFN]-gamma+ IL-12 )
induces a much stronger type 1 immune response than BMDC0 (
GM-CSF + IL-3 )
Krinner et al., Mol Immunol 2007
:
As a consequence, the antibody potently prevented both
GM-CSF induced proliferation of TF-1 cells with a sub-nanomolar IC50 value and the production of the chemokine
IL-8 by U937 cells
Leizer et al., Blood 1990
:
Cytokine regulation of colony stimulating factor production in cultured human synovial fibroblasts : I.
Induction of
GM-CSF and G-CSF production by
interleukin-1 and tumor necrosis factor
Duan et al., Invest Ophthalmol Vis Sci 2007
(Keratitis, Herpetic) :
GM-CSF stimulation of neutrophils
induced their activation and the secretion of
IL-8
Lambert et al., J Biol Chem 2007
(Respiratory Tract Infections) :
The alpha, beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage
colony stimulating factor , interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not
inhibit production of
IL-8
Wirotesangthong et al., Int Immunopharmacol 2008
:
PE significantly decreased histamine and
GM-CSF produced by an IgE mediated hypersensitive reaction, and
inhibited eotaxin and
IL-8 secretion in a TNF-alpha and IL-4 induced allergic reaction
Pazdrak et al., J Immunol 2008
:
Importantly, we found that inhibition of ICAM-1 in activated eosinophils blocked
GM-CSF induced expression of c-fos, c-myc,
IL-8 , and TNF-alpha
Fuxman Bass et al., Mol Immunol 2008
:
Granulocyte-macrophage
colony stimulating factor increased
IL-8 and IL-1beta secretion, and CD11b-upregulation induced by single stranded bacterial DNA
Essner et al., J Clin Lab Immunol 1990
:
Differential
effects of granulocyte-macrophage
colony stimulating factor and macrophage colony stimulating factor on tumor necrosis factor and
interleukin-1 production in human monocytes
Nozaki et al., J Invest Dermatol 1991
:
Augmentation of granulocyte/macrophage
colony stimulating factor expression by ultraviolet irradiation is
mediated by
interleukin 1 in Pam 212 keratinocytes
Wang et al., Int J Oncol 1995
:
We report that all-trans retinoic acid ( tRA ) synergizes with LPS to
enhance the production of granulocyte
colony stimulating factor ( G-CSF ) in PMA treated cells, whereas the production of granulocyte-macrophage CSF,
interleukin 1-beta (IL-1-beta), and tumor necrosis factor-alpha (TNF-alpha) is minimally affected by tRA
Rodriguez-Cimadevilla et al., Blood 1990
(Leukemia, Myeloid, Acute) :
Coordinate secretion of interleukin-1 beta and granulocyte-macrophage
colony stimulating factor by the blast cells of acute myeloblastic leukemia :
role of
interleukin-1 as an endogenous inducer
Szardien et al., Eur Heart J 2012
(Aortic Valve Stenosis...) :
Regression of cardiac hypertrophy by granulocyte
colony stimulating factor stimulated
interleukin-1ß synthesis
Maeda et al., Vet Immunol Immunopathol 2013
(Dermatitis, Atopic) :
Stimulation of CPEK cells with trypsin induced significant upregulation of the mRNA expression levels of tumor necrosis factor alpha ( TNF-a, P < 0.05 ), granulocyte-macrophage
colony stimulating factor ( GM-CSF, P < 0.01 ), thymus and activation
regulated chemokine ( TARC/CCL17, P < 0.01 ), and
interleukin 8 ( IL-8/CXCL8, P < 0.01 )
Suzuki et al., J Perinatol 2013
:
Serum levels of IL-6 and
IL-8 had been already elevated in his cord blood, and serum levels of granulocyte-macrophage
colony stimulating factor and IL-8 were significantly
increased on the second day of life
Bradbury et al., Leukemia 1990
(Leukemia, Myeloid, Acute) :
Endogenous
interleukin-1 can
regulate the autonomous growth of the blast cells of acute myeloblastic leukemia by inducing autocrine secretion of
GM-CSF
Bot et al., Blood 1989
:
Human multilineage
colony stimulating factor ( multi-CSF )
/interleukin-3 (IL-3)
induces colony formation from CFU-GEMM, BFU-E, and CFU-Eo when applied to in vitro cultures of highly enriched hematopoietic progenitor cells
Morrissey et al., Int Arch Allergy Appl Immunol 1989
(Chagas Disease) :
Thus, we have found that exogenous
GM-CSF augments the primary plaque forming response to sheep red blood cells and that this effect is
due to upregulation of Ia antigen expression and
interleukin 1 production by the macrophages
Motoyoshi et al., Exp Hematol 1989
:
On the other hand,
CSF-HU did not
stimulate monocyte production of
interleukin-1 and interferon
Kleinerman et al., Cancer Res 1988
(Neoplasms) :
rGM-CSF in vitro also did not
stimulate the tumoricidal function of normal monocytes or the secretion of
interleukin-1 or tumor necrosis factor
Hachicha et al., J Exp Med 1995
(Gout...) :
Both TNF-alpha and
GM-CSF stimulated
IL-8 production ; however, only TNF-alpha exerted a significant effect on MIP-1 alpha secretion in neutrophils ...
IL-8 production
induced by TNF-alpha and
GM-CSF was synergistically enhanced in the presence of MSU or CPPD, whereas MIP-1 alpha secretion induced by TNF was completely inhibited in the presence of either MSU or CPPD
Murata et al., Neurol Med Chir (Tokyo) 1993
(Glioblastoma) :
Exogenous
GM-CSF stimulation
had no effect on production of prostaglandin E2,
interleukin-6 , or interleukin-8 by glioma cells
Arnold et al., Immunology 1994
(Respiratory Syncytial Virus Infections) :
In addition, IL-3,
G-CSF , IFN-gamma and TGF-beta 2, albeit at high concentrations,
induced a low
IL-8 release from non infected A549 cells
Takahashi et al., Blood 1993
:
Effect of granulocyte-macrophage
colony stimulating factor and interleukin-3 on
interleukin-8 production by human neutrophils and monocytes ... Neutrophils produce
IL-8 in
response to
GM-CSF but not to IL-3 ... In contrast, recombinant human
granulocyte-CSF ( rhG-CSF ), at concentrations as high as 100 ng/mL, does not
induce IL-8 in either cell type ...
rhGM-CSF also
induces IL-8 mRNA expression and IL-8 protein in the promonocytic cell line, U-937, whereas rhG-CSF does not ... Stimulation of neutrophils with
rhGM-CSF resulted in an increase in cell associated
IL-8 at 4 hours ... rhGM-CSF, and to a lesser degree rhIL-3, potently stimulated IL-8 secretion in cultures of heparinized whole blood, whereas
rhG-CSF had no significant effect on
IL-8 secretion ...
Induction of
IL-8 by
GM-CSF may be physiologically important in enhancing the acute inflammatory response
Yokoshima et al., Nihon Jibiinkoka Gakkai Kaiho 1995
(Nose Neoplasms...) :
Immunohistochemical study revealed the distribution of cytokines :
GM-CSF was
detected near the basement membrane of the tumor site, while IL-6 and
IL-8 were detected in the superficial layer of nasal inverted papilloma
Pullyblank et al., Br J Cancer 1994
(Adenocarcinoma...) :
Similarly,
interleukin 2 receptor (IL-2R) expression ( percentage of positive cells ) was augmented in the
presence of m17-1A ( 15 +/- 3 ), c17-1A ( 14 +/- 3 ) and
cSF25 ( 25 +/- 3 ) when compared with no antibody ( 9 +/- 2 )
Rizzo et al., Exp Hematol 1994
:
Regulation of
interleukin-1 and tumor necrosis factor-alpha
induced granulocyte-macrophage
colony stimulating factor gene expression : potential involvement of arachidonic acid metabolism
Akahane et al., Exp Hematol 1993
:
In the present study, we show that
GM-CSF production in murine aorta derived vascular endothelial cells is
regulated by two cytokines
: interleukin-1 (IL-1), which induces the production of GM-CSF, and interferon gamma (IFN-gamma), which downregulates this production
McCain et al., Am J Respir Cell Mol Biol 1993
:
Since both IL-8 and GM-CSF accumulate in sites of acute inflammation, PMN may induce
IL-8 gene expression in
response to
GM-CSF and thereby amplify the acute inflammatory response by recruiting additional PMN into inflammatory sites
Mori et al., Rinsho Ketsueki 1993
(Eosinophilia...) :
The activity of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) was
detected in the supernatant of the cultured ATL cells, although interleukin-3,
interleukin-5 , and GM-CSF activities were not detected in her serum
Hashimoto et al., Exp Hematol 1996
:
Macrophage
colony stimulating factor induces
interleukin-8 production in human monocytes ... We have investigated the stimulatory
effect of recombinant human macrophage
colony stimulating factor ( rhM-CSF ) on
interleukin-8 (IL-8) production by human peripheral blood monocytes
van Pelt et al., Blood 1996
:
GM-CSF induced the release of
interleukin-8 (IL-8) , but not of IL-6 or tumor necrosis factor alpha
Le Meur et al., Kidney Int 1996
(Uremia) :
Since macrophage
colony stimulating factor ( M-CSF ) is
essential for the activation of several functions of monocytes and macrophages and their production of cytokines such as
interleukin-1 , interleukin-6, and tumor necrosis factor alpha, we investigated its involvement in patients with CRF
Rougier et al., Cytokine 1998
:
IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage
colony stimulating factor ( GM-CSF ) ( at 10 ng/ml )
stimulated IL-6 and
IL-8 production in 0 % and 10 % FCS
Ure et al., Br J Dermatol 1998
(Arthralgia...) :
Granulocyte/macrophage
colony stimulating factor increases wound-fluid
interleukin 8 in normal subjects but does not accelerate wound healing ... However,
GM-CSF increases
IL-8 release, which is a potent chemotactic cytokine, indicating that GM-CSF might be of therapeutic value under conditions of impaired chemotaxis
Murphy et al., J Biol Chem 1998
(Alzheimer Disease) :
Macrophage
colony stimulating factor augments beta-amyloid
induced interleukin-1,
interleukin-6 , and nitric oxide production by microglial cells ... We showed that macrophage
colony stimulating factor , a microglial activator found at increased levels in the central nervous system in AD, dramatically
augments beta-amyloid peptide ( betaAP ) -induced microglial production of
interleukin-1 , interleukin-6, and nitric oxide